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PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). Although approved for use in EGFR-overexpressing advanced colorectal cancer, recent studies haveExpand
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Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer*
Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in clinical trials.Expand
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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling toExpand
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Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defectsExpand
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Population-Attributable Risk Estimates for Risk Factors Associated with Campylobacter Infection, Australia
One-sentence summary: Each year, an estimated 50,500 cases in persons >5 years of age can be directly attributed to consumption of chicken.
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Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.
5-Fluorouracil (5-FU) is the most common chemotherapeutic agent used in the treatment of colorectal cancer, yet objective response rates are low. Recently, camptothecin (CPT) has emerged as anExpand
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HDAC4 promotes growth of colon cancer cells via repression of p21.
The class II Histone deacetylase (HDAC), HDAC4, is expressed in a tissue-specific manner, and it represses differentiation of specific cell types. We demonstrate here that HDAC4 is expressed in theExpand
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Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation.
BACKGROUND & AIMS The short-chain fatty acid butyrate induces cell cycle arrest, differentiation, and apoptosis in colon cancer cells, but often induces opposite effects in normal colonic epithelialExpand
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Short-chain fatty acids promote the migration of colonic epithelial cells in vitro.
BACKGROUND & AIMS Repair of colonic epithelial erosions requires cell migration. This study aimed to examine the effects of physiologically relevant short-chain fatty acids on migration in colonicExpand
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Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
The receptor tyrosine kinase EPHB2 has recently been shown to be a direct transcriptional target of TCF/beta-catenin. Premalignant lesions of the colon express high levels of EPHB2 but the expressionExpand
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