Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation.
- A. Wilson, J. Symons, T. L. McDowell, H. Mcdevitt, G. Duff
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1997
Tumor necrosis factor alpha (TNF alpha) is a potent immunomodulator and proinflammatory cytokine that has been implicated in the pathogenesis of autoimmune and infectious diseases. For example,… Expand
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
- N. Craddock, M. E. Hurles, +214 authors P. Donnelly
- Biology
- 2010
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this… Expand
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles
- A. Wilson, N. de Vries, F. Pociot, F. D. di Giovine, L. B. van der Putte, G. Duff
- Biology, Medicine
- The Journal of experimental medicine
- 1 February 1993
The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have… Expand
Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.
- A. Wilson, F. D. di Giovine, A. Blakemore, G. Duff
- Biology, Medicine
- Human molecular genetics
- 1 August 1992
Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in…
Objective: To determine whether rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibodies, or carriage of shared epitope (SE) and PTPN22 genetic susceptibility variants predict… Expand
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
Background Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases. Objective To… Expand
Association of Interleukin-6 and Interleukin-10 Genotypes With Radiographic Damage in Rheumatoid Arthritis Is Dependent on Autoantibody Status
- I. Marinou, J. Healy, +6 authors A. Wilson
- Medicine
- Arthritis and rheumatism
- 1 August 2007
Objective Recent evidence has highlighted a major genetic contribution to radiographic damage in rheumatoid arthritis (RA). The objective of this study was to determine whether genetic variants in… Expand
Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases.
- A. Wilson
- Biology, Medicine
- Journal of periodontology
- 1 August 2008
Epigenetics can be defined as all the meiotically and mitotically inherited changes in gene expression that are not encoded in the DNA sequence itself. Epigenetic modifications of chromatin and DNA… Expand
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
- N. Zaitlen, S. Lindström, +45 authors Alkes L. Price
- Biology, Medicine
- PLoS genetics
- 1 November 2012
Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or… Expand
Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls
- N. Craddock, M. Hurles, +214 authors P. Donnelly
- Biology, Medicine
- Nature
- 1 April 2010
Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this… Expand