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Mechanisms of caffeine activation of single calcium‐release channels of sheep cardiac sarcoplasmic reticulum.
1. Calcium‐release channels of sheep cardiac junctional sarcoplasmic reticulum were incorporated into planar phospholipid bilayers. Single‐channel current fluctuations were recorded under voltageExpand
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Divalent cation activation and inhibition of single calcium release channels from sheep cardiac sarcoplasmic reticulum
Single Ca2+ release channels from vesicles of sheep cardiac junctional sarcoplasmic reticulum have been incorporated into uncharged planar lipid bilayers. Single-channel currents were recorded fromExpand
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A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum
A model is developed for ionic conduction in the sheep cardiac sarcoplasmic reticulum ryanodine receptor channel based on Eyring rate theory. A simple scheme is proposed founded on single-ionExpand
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Modification of the gating of the cardiac sarcoplasmic reticulum Ca(2+)-release channel by H2O2 and dithiothreitol.
The effect of hydrogen peroxide (H2O2) on the sheep cardiac sarcoplasmic reticulum (SR) Ca(2+)-release channel has been investigated under voltage-clamp conditions after incorporation of nativeExpand
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Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations
The sarcoplasmic reticulum Ca(2+)-release channel plays a central role in cardiac muscle function by providing a ligand-regulated pathway for the release of sequestered Ca2+ to initiate contractionExpand
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CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy.
Chloride intracellular channel 2 (CLIC2), a newly discovered small protein distantly related to the glutathione transferase (GST) structural family, is highly expressed in cardiac and skeletalExpand
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Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions.
OBJECTIVE The aim was to perform a theoretical and experimental study of the possible variations in Ca2+ current through the open cardiac sarcoplasmic reticular Ca2+ release channel under the ionicExpand
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Light at the end of the Ca2+-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels
1. Introduction 62 2. Channel structure 63 2.1 Isoforms, primary structure and topology of Ca2+-release channels 63 2.2 Identification of ligand binding sites within the primary sequence of RyR 65Expand
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The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor.
The effects of ATP, ADP, and inorganic phosphate (Pi) on the gating of native sheep cardiac ryanodine receptor channels incorporated into planar phospholipid bilayers were investigated. WeExpand
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Sheep cardiac sarcoplasmic reticulum calcium‐release channels: modification of conductance and gating by temperature.
1. The gating and conduction properties of single calcium‐release channels of sheep isolated cardiac junctional sarcoplasmic reticulum membranes incorporated into planar phospholipid bilayers wereExpand
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