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Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is overexpressed in most colorectal carcinomas and a subset of colorectal adenomas. Genetic, biochemical, and clinical… Expand
Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia.
Aberrant activation of beta-catenin promotes cell proliferation and initiates colorectal tumorigenesis. However, the expansion of tumours and the inadequacy of their local vasculature results in… Expand
Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence.
Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with… Expand
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
Aberrant activation of β-catenin promotes cell proliferation and initiates colorectal tumorigenesis. However, the expansion of tumours and the inadequacy of their local vasculature results in areas… Expand
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment.
- D. Qualtrough, A. Buda, William Gaffield, A. Williams, C. Paraskeva
- Biology, Medicine
- International journal of cancer
- 20 July 2004
Hedgehog (Hh) signalling controls many aspects of development. It also regulates cell growth and differentiation in adult tissues and is activated in a number of human malignancies. Hh and Wnt… Expand
The cell biology of MHC class I antigen presentation.
MHC class I antigen presentation refers to the co-ordinated activities of many intracellular pathways that promote the cell surface appearance of MHC class I/beta2m heterodimers loaded with a… Expand
Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.
- S. Chell, A. Kaidi, A. Williams, C. Paraskeva
- Medicine, Biology
- Biochimica et biophysica acta
- 1 August 2006
Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal tumours are considered preventable, trends toward increasing obesity suggest the potential for a further… Expand
The incidence of impacted teeth. A survey at Harlem hospital.
Abstract 1. 1. Among the roentgenograms examined, 18.2 per cent demonstrate one or more impactions. 2. 2. Third molar impactions represent 94.8 per cent of all impactions. 3. 3. Maxillary third molar… Expand
Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk
- Katy J Petherick, A. Williams, +8 authors A. Greenhough
- Medicine, Biology
- The EMBO journal
- 8 December 2012
The Wnt/β‐catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β‐catenin signalling pathway as… Expand
An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis
As tumours are known to acidify their microenvironment and fluctuations in lumenal pH have been reported in a number of colonic disease conditions, we investigated whether loss of p53 function,… Expand