• Publications
  • Influence
On the importance--and the unimportance--of birthweight.
  • A. Wilcox
  • Medicine
  • International journal of epidemiology
  • 1 December 2001
TLDR
Evidence presented here suggests the link between birthweight and health outcomes may not be causal, and methods of analysis that assume causality are unreliable at best, and biased at worst. Expand
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
TLDR
Replication studies from several populations showed confirming evidence, with families of European ancestry giving strong evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4, and expression studies support a role for MAFBs in palatal development. Expand
A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting.
TLDR
A log-linear method for analysis of case-parent-triad data, based on maximum likelihood with stratification on parental mating type, which generalizes easily to accommodate maternal effects on risk and produces powerful and orthogonal tests of the contribution of fetal versus maternal genetic factors. Expand
Likelihood of conception with a single act of intercourse: providing benchmark rates for assessment of post-coital contraceptives.
TLDR
It is found that the possibility of late ovulation produces a persistent risk of pregnancy even into the sixth week of the cycle, and post-coital contraceptives may be indicated even when intercourse has occurred late in the cycle. Expand
Incidence of early loss of pregnancy.
TLDR
The total rate of pregnancy loss after implantation, including clinically recognized spontaneous abortions, was 31 percent and most of the 40 women with unrecognized early pregnancy losses had normal fertility, since 95 percent of them subsequently became clinically pregnant within two years. Expand
Use of time to pregnancy to study environmental exposures.
TLDR
To evaluate problems with collecting data on time to pregnancy, telephone interviews were conducted with nearly 700 pregnant women who reported having planned their pregnancies and power curves indicate that relatively small sample sizes are sufficient for investigating an exposure. Expand
Time of implantation of the conceptus and loss of pregnancy.
TLDR
In most successful human pregnancies, the conceptus implants 8 to 10 days after ovulation, and the risk of early pregnancy loss increases with later implantation. Expand
Disruption of an AP-2α binding site in an IRF6 enhancer is strongly associated with cleft lip
TLDR
These findings place IRF6 and AP-2α in the same developmental pathway and identify a high-frequency variant in a regulatory element contributing substantially to a common, complex disorder. Expand
Cigarette smoking associated with delayed conception.
TLDR
Fertility was not affected by the husband's smoking, and data provide evidence that reduced fertility should be added to the growing list of reproductive hazards of cigarette smoking. Expand
Placental abruption and perinatal mortality in the United States.
TLDR
The link between fetal growth restriction and abruption suggests that the origins of abruption lie at least in midpregnancy and perhaps even earlier, and the high risk of perinatal death associated with abruption persisted. Expand
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