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Behavioral and biochemical effects of the 5-HT1A receptor agonists flesinoxan and 8-OH-DPAT in the rat.
TLDR
The 5-HT1A receptor agonists flesinoxan and 8-hydroxy-2-(di-n-propylamino)tetralin produced a dose-dependent facilitation of male rat ejaculatory behavior and characteristic, dose- dependent effects on spontaneous motor activity, which decreased total locomotor activity and rearing activity but increased forward locomotion and peripheral locomotion. Expand
Increased dopamine turnover in the ventral striatum by 8‐OH‐DPAT administration in the rat
TLDR
The present results suggest that 8‐OH‐DPAT, depending on the experimental conditions, is an agonist or antagonist at striatal DA receptors, in all probability due to partial DA receptor agonist properties of the compound. Expand
Plasma protein binding of sulphadiazine, sulphamethoxazole and trimethoprim determined by ultrafiltration.
TLDR
The significantly lower protein binding of sulphadiazine compared to sulphamethoxazole means that equivalent non-protein bound plasma levels of the two sulphonamides are achieved from smaller doses of co-trimazine than co- Trimxazole, and use ofCo-trIMazine may thus minimize the risk of adverse reactions. Expand
Determination of sulfadiazine and N4-acetylsulfadiazine in biological fluids by liquid chromatography on silica gel with an aqueous buffer as mobile phase.
TLDR
Sulfadiazine and N4-acetylsulf adiazine were determined in biological fluids by the direct injection (plasma after protein precipitation and urine after dilution 100 times) of 20 microliters on a silica gel column and Chromatographic selectivity was optimized by the silica Gel surface and pH of the mobile phase. Expand
Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis.
The effects of the 5-HT1A receptor agonists 8-OH-DPAT (0.15-2.5 mumol kg-1 subcutaneously), flesinoxan (0.6-10.0 mumol kg-1 subcutaneously) and buspirone (1.9-30.0 mumol kg-1 subcutaneously) onExpand
Effects of postpuberal castration on dopamine receptor sensitivity in the male rat brain.
TLDR
Results indicate an enhanced DA receptor sensitivity at both pre- and post-synaptic sites, as assessed by the dihydroxyphenylalanine accumulation after NSD-1015 treatment. Expand
Behavioural and biochemical effects of subchronic treatment with raclopride in the rat: tolerance and brain monoamine receptor sensitivity.
TLDR
There was an increase in locomotor activity by the apomorphine treatment in animals pretreated with the 8 mg kg-1 dose, as compared to the response obtained in saline controls, and there was an increased DA receptor sensitivity presynaptically as evidenced by an enhanced effect on striatal DOPA levels by apomorphicine in rats treated with NSD 1015 and reserpine. Expand
Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.
TLDR
Twenty derivatives bearing substituents on the phenolic function of (-)-3-(3-hydroxyphenyl)-N-propylpiperidine were synthesized and tested as prodrugs, and especially the 4-isopropylphenylcarbamate 20 was capable of escaping the first-pass metabolism and still generating high plasma levels of the parent compound. Expand
Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat
TLDR
It is concluded that 8-OH-DPAT, in addition to general effects on forebrain 5-hydroxytryptamine synthesis, selectively affects limbic forebrain dopamine synthesis. Expand
Stimulation of brain dopamine autoreceptors by remoxipride administration in reserpine‐treated male rats
TLDR
Reserpine produced a marked increase in striatal and neocortical dopa accumulation, in comparison with glucose vehicle + NSD‐1015‐treated controls, and this increase was dose‐dependently antagonized by remoxipride treatment, which could contribute to the favourable endocrine and extrapyramidal side effect profile of remxipride as an antipsychotic agent. Expand
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