A. Wickenden

Publications88
h-index35
Citations3,307
Highly Influential Citations190
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Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Retigabine [N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid; D-23129] is a novel anticonvulsant, unrelated to currently available antiepileptic agents, with activity in a broad range of… Expand
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Stoichiometry of Expressed KCNQ2/KCNQ3 Potassium Channels and Subunit Composition of Native Ganglionic M Channels Deduced from Block by Tetraethylammonium
KCNQ2 and KCNQ3 potassium-channel subunits can form both homomeric and heteromeric channels; the latter are thought to constitute native ganglionic M channels. We have tried to deduce the… Expand
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N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current. In humans, mutations in these genes lead to a rare form of neonatal epilepsy (Biervert et… Expand
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Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.
Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a transferrin-independent process. We examined the ability… Expand
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Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells
Heteromeric KCNQ5/Q3 channels were stably expressed in Chinese Hamster ovary cells and characterized using the whole cell voltage‐clamp technique. KCNQ5/Q3 channels were activated by the novel… Expand
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Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)
Background: The molecular basis for sodium channel inhibition by spider venom peptides is poorly understood. Results: Key toxin residues and structural features important for activity of… Expand
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
An increasing body of evidence suggests that the purinergic receptor P2X, ligand‐gated ion channel, 7 (P2X7) in the CNS may play a key role in neuropsychiatry, neurodegeneration and chronic pain. In… Expand
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Effects of Development and Thyroid Hormone on K+ Currents and K+ Channel Gene Expression in Rat Ventricle
1 In rat heart, three K+ channel genes that encode inactivating transient outward (ITO)‐like currents are expressed. During development the predominant K+ channel mRNA species switches from Kv1.4 to… Expand
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Activation of TRPA1 by Farnesyl Thiosalicylic Acid
The nonselective cation channel TRPA1 (ANKTM1, p120) is a potential mediator of pain, and selective pharmacological modulation of this channel may be analgesic. Although several TRPA1 activators… Expand
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Effect of Cd2+ on Kv4.2 and Kv1.4 Expressed in Xenopus Oocytes and on the Transient Outward Currents in Rat and Rabbit Ventricular Myocytes
The aim of the present study was to compare the biophysical properties and Cd2+ sensitivity of Kv4.2 and Kv1.4 in Xenopus oocytes with those of native transient outward potassium currents in rat and… Expand
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