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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell… Expand
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is curable in less than 50% of patients. Prognostic models based on pre-treatment characteristics, such as the… Expand
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so… Expand
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and maintenance. Starting from an… Expand
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
- A. Weng, Yunsun Nam, +4 authors J. Aster
- Biology, Medicine
- Molecular and Cellular Biology
- 15 January 2003
ABSTRACT Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immature T-cell lymphoblastic neoplasms (T-ALLs). Although it is clear that Notch signaling can initiate… Expand
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals are not well… Expand
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB) development. Notch pathway activation induces… Expand
Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.
Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is characterized by the hallmark translocation t(11;14)(q13;q32) and the resulting overexpression of cyclin D1 (CCND1). Our… Expand
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Notch1 signaling drives T cell development at the expense of B cell development from a common precursor, an effect that is dependent on a C-terminal Notch1 transcriptional activation domain. The… Expand
Structural Requirements for Assembly of the CSL·Intracellular Notch1·Mastermind-like 1 Transcriptional Activation Complex*
- Yunsun Nam, A. Weng, J. Aster, S. Blacklow
- Biology, Medicine
- Journal of Biological Chemistry
- 6 June 2003
Ligand binding by Notch receptors triggers a series of proteolytic cleavages that liberate the intracellular portion of Notch (ICN) from the cell membrane, permitting it to translocate to the… Expand