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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
It is reported that HDACIs induce, in addition to p21, expression of TRAIL by directly activating the TNFSF10 promoter, thereby triggering tumor-selective death signaling in acute myeloid leukemia (AML) cells and the blasts of individuals with AML. Expand
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.
NO donors may up-regulate the activity of the human VEGF promoter in normoxic human glioblastoma and hepatoma cells independent of a cyclic guanosine monophosphate-mediated pathway and a difference in sensitivity to guanylate cyclase inhibitors and a different pattern of HIF-1 binding. Expand
Identification of Hypoxia-inducible Factor 1 Ancillary Sequence and Its Function in Vascular Endothelial Growth Factor Gene Induction by Hypoxia and Nitric Oxide*
- H. Kimura, A. Weisz, +6 authors H. Esumi
- Biology, Medicine
- The Journal of Biological Chemistry
- 19 January 2001
Gel shift assays demonstrate that as yet unknown protein complexes constitutively bind to the HAS regardless of the presence of these stimuli in several cell lines, in contrast with hypoxia- or NO-induced activation of HIF-1 binding to the HBS. Expand
The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.
This work identified the RNA binding protein SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) as a component of the hepatocyte exosomal miRNA sorting machinery and identified the hEXO motif, which has a role in the regulation of miRNA localization. Expand
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.
An estrogen-responsive regulatory region has been mapped within the first 944 bp upstream of the transcriptional startsite of the human D(1) gene and sequence analysis of this DNA region reveals that the cis-acting elements responsive to estrogen are likely to be different in this case from the canonical EREs. Expand
Estrogens and Progesterone Promote Persistent CCND1 Gene Activation during G1 by Inducing Transcriptional Derepression via c-Jun/c-Fos/Estrogen Receptor (Progesterone Receptor) Complex Assembly to a…
- L. Cicatiello, R. Addeo, +11 authors A. Weisz
- Biology, Medicine
- Molecular and Cellular Biology
- 15 August 2004
It is reported here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor α complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent. Expand
Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation
Results indicate that the vast majority of the genomic targets of ER β can bind also ERα, suggesting that the overall action of ERβ on the genome of hormone-responsive BC cells depends mainly on the relative concentration of both ERs in the cell. Expand
RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer
Evidence of an active piRNA pathway in BC suggests that these small non-coding RNAs do exert transcriptional and post-transcriptional gene regulatory actions also in cancer cells. Expand
Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs.
- L. Cicatiello, M. Mutarelli, +12 authors A. Weisz
- Biology, Medicine
- The American journal of pathology
- 1 May 2010
A comprehensive genome-wide analysis was performed in estrogen stimulated MCF-7 and ZR-75 cells to identify the molecular determinants of this hormone-responsive tumor phenotype, and 1270 genes that were found to respond to 17beta-estradiol were found. Expand
Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
It is reported that activation of PI3K/AKT pathway in Italian NSCLC patients is associated with high grade (G3–G4 compared with G1–G2) and more advanced disease (TNM stage III vs. stages I and II; n = 26; p<0.05) and only p110α overexpression was significantly associated to AKT activation in NSCLCs. Expand