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BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture.
This study addresses synergistic effects of bone morphogenetic protein-2 (BMP-2) and transforming growth factor-beta3 (TGF-beta3) in the induction of chondrocytic differentiation of bone marrowExpand
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Expression and regulation of peroxiredoxin 5 in human osteoarthritis
Reactive oxygen species (ROS) are implicated in the pathogenesis of osteoarthritis (OA). However, little is known about the antioxidant defence system in articular cartilage. We investigated theExpand
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The role of BMP‐7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro
This study addresses the role of bone morphogenetic protein‐7 (BMP‐7) in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. BMExpand
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BMP-13 Emerges as a Potential Inhibitor of Bone Formation
Bone morphogenetic protein-13 (BMP-13) plays an important role in skeletal development. In the light of a recent report that mutations in the BMP-13 gene are associated with spine vertebral fusion inExpand
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Differentiation of rodent bone marrow mesenchymal stem cells into intervertebral disc-like cells following coculture with rat disc tissue.
This study aimed to evaluate whether rat mesenchymal stem cells (rMSCs) could be differentiated in vitro into disc-like cells by coculturing with intervertebral disc tissue. rMSCs were cultured withExpand
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The fate of transplanted xenogeneic bone marrow‐derived stem cells in rat intervertebral discs
Intervertebral disc degeneration is a major cause and a risk factor for chronic low back pain. The potential of using stem cells to treat disc degeneration has been raised. The aims of our study wereExpand
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Antioxidant enzyme peroxiredoxin 5 is upregulated in degenerative human tendon.
Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in a variety of human cells and tissues, which is considered to play an important role in oxidative stress protectionExpand
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BMP13 Prevents the Effects of Annular Injury in an Ovine Model
Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a majorExpand
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Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis.
BACKGROUND CONTEXT Disc degeneration includes dysfunction and loss of disc cells leading to a decrease in extracellular matrix (ECM) components. Apoptosis has been identified in degenerated discs.Expand
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Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon
We investigated the temporal expressions of the three nitric oxide synthase (NOS) isoforms by semi‐quantitative polymerase chain reaction (PCR) assays and by immunoblot analysis, following AchillesExpand
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