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Drugs of abuse screening in urine as part of a metabolite-based LC-MSn screening concept
The presented LC-MSn method complements the well-established gas chromatography-mass spectroscopy procedure in the authors’ laboratory and could be used for drug screening in clinical and forensic toxicology and in doping control. Expand
Development of the first metabolite-based LC-MSn urine drug screening procedure-exemplified for antidepressants
The presentedLC-MSn method complements established GC-MS or LC-MS procedures in the authors’ lab and allowed detecting unknown compounds based on known fragment structures and confirms the body passage. Expand
Validated electrospray liquid chromatographic–mass spectrometric assay for the determination of the mushroom toxins α- and β-amanitin in urine after immunoaffinity extraction
Abstract Specific detection of amanitins in body fluids is necessary for an early diagnosis of an intoxication with amanita mushrooms. In this paper, a liquid chromatographic-mass spectrometric assayExpand
Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric
The validated LC/MS assay has proved to be appropriate for the isolation, separation, screening, identification and quantification of various neuroleptics in plasma for clinical toxicology and therapeutic drug monitoring purposes. Expand
Mass spectral and GC data of drugs, poisons, pesticides, pollutants and their metabolites: Part 3 mass spectra (m/z222 to 777 amu).
Volume 1 (Methods, Tables). Methods. 1 Introduction. 2 Experimental Section. 2.1 Origin and choice of samples. 2.2 Sample preparation. 2.2.1 Standard extraction procedures. StandardExpand
Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass
The quantification assay is part of a general LC-MS procedure for fast screening, identification and quantification of different toxicologically relevant compounds in plasma and has proven to be appropriate for OADs. Expand
Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular drugs.
The novel LC-HR-MS/MS method allowed fast, simple, and robust urine screening, particularly for cardiovascular drugs showing the usefulness of Orbitrap technology for drug testing. Expand
A validated GC-MS procedure for fast, simple, and cost-effective quantification of glycols and GHB in human plasma and their identification in urine and plasma developed for emergency toxicology
The new method is fast and simple and designed for the simultaneous determination of ethylene glycol, 1,2-propylene gly col, lactic acid, glycolic acid, gamma-hydroxybutyric acid (GHB), diethylene glyCol, triethylene gly COL, and tetraethylenes glycol in human plasma or urine. Expand
Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution
The aim of this present study was to identify the phase I and II metabolites of SG in rat urine after the administration of a rather high dose of the pure alkaloid and then to confirm these findings using human urine samples after Kratom use, using liquid chromatography coupled to low and high-resolution mass spectrometry. Expand