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A classical enzyme active center motif lacks catalytic competence until modulated electrostatically.
The cysteine proteinase superfamily is a source of natural structural variants of value in the investigation of mechanism. It has long been considered axiomatic that catalytic competence of these…
Metal and redox modulation of cysteine protein function.
A computational analysis of SARS cysteine proteinase-octapeptide substrate interaction: implication for structure and active site binding mechanism
- Krongsakda Phakthanakanok, K. Ratanakhanokchai, K. L. Kyu, P. Sompornpisut, A. Watts, S. Pinitglang
- Biology, ChemistryBMC Bioinformatics
- 30 January 2009
The hypothesis proposed that Glu47 of SARS CoVMpro is an important residue in the S3 subsite and is involved in binding with P3Lys of the octapeptide.
Characterization of the hydrolytic activity of a polyclonal catalytic antibody preparation by pH-dependence and chemical modification studies: evidence for the involvement of Tyr and Arg side chains…
Evidence from the kinetic and chemical modification studies and from studies on the pH-dependence of binding suggests that catalysis involves assistance to the reaction of the substrate with hydroxide ions by hydrogen-bond donation at the reaction centre by tyrosine and arginine side chains.
A Method for Screening Baeyer-Villiger Monooxygenase Activity Against Monocyclic Ketones
A specific colorimetric screening method that utilises an esterase to cleave the lactone that is formed in the BVMO reaction and has been demonstrated with cyclohexanone monooxygenase from A. calcoaceticus.
The theory and application of transition state pK(a) values: the reaction of papain with a series of trimethylene disulphide reactivity probes.
The application of transition state pK(a) values to describe the relationship between molecular recognition and the transition state for the catalytic mechanism of papain is reported here for the first time.
Structural studies of vanadium haloperoxidases : Insight into halide specificity, stability, and enzyme mechanism
Crystallographic studies of the vanadium haloperoxidase found in Corallina red algae has revealed details of the structure of these enzymes which has increased our understanding of halide…