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Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma.
To investigate the role of IL-5 in airway hyperreactivity and pulmonary eosinophilia, we used a model of allergic asthma in guinea pigs and a neutralizing monoclonal antibody (TRFK-5) directedExpand
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Characterization of a murine model of allergic pulmonary inflammation.
Pulmonary inflammation with eosinophil (EOs) infiltration is a prominent feature of allergic respiratory diseases such as asthma. In order to study the cellular response during the diseaseExpand
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Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung.
Based on its involvement in eosinophil biology, interleukin 5 (IL-5) may play a role in the pulmonary eosinophilia associated with allergic reactions. We have examined that hypothesis using aExpand
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Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody.
Interleukin-5 (IL-5) is important in the control of differentiation, migration, and activation of eosinophils. In order to study the role of IL-5 in the development of eosinophilic inflammation ofExpand
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Mechanisms of allergic pulmonary eosinophilia in the mouse.
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Anti-androgenicity of flutamide and its metabolite Sch 16423.
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Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent,
Eosinophil infiltration into bronchoalveolar areas of the lung has been assessed in guinea pigs sensitized to ovalbumin (OA) and then challenged with the aerosolized antigen. Cell content, histamine,Expand
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A study of the mechanism of Con A-induced immunosuppression in vivo.
The plaque-forming cell (PFC) response to sheep erythrocytes (SRBC) is suppressed in a dose-related manner when concanavalin A (Con A) is administered intravenously to mice prior to or afterExpand
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Survival of Skin Homografts in Uteri of Pregnant and Progesterone-Estrogen Treated Rats∗
Summary Skin homografts placed in uteri of nonpregnant intact or castrate rats evoke a local inflammatory reaction followed by rejection with 9 days. Similar results are obtained with rats treatedExpand
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Inhibition of collagen II arthritis by simultaneous administration of concanavalin A and other substances with antigen emulsion.
Several pharmacological agents, some of which are known to have effects on the immune system, decrease the incidence of collagen II-induced arthritis when added to the antigen emulsion. ConcanavalinExpand
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