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Associations with covid-19 hospitalisation amongst 406,793 adults: the UK Biobank prospective cohort study
TLDR
Understanding why these factors confer increased risk of severe covid-19 in the population may help elucidate the underlying mechanisms as well as inform strategy and policy to prevent this disease and its consequences.
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
TLDR
It is suggested that intraocular rather than systemic modulation of complement may prove more effective in relation to age-related macular degeneration and this has important implications for designing novel complement-based AMD therapies.
Prevalence of referable, sight-threatening retinopathy in type 1 diabetes and its relationship to diabetes duration and systemic risk factors
TLDR
T1DM duration is a strong risk factor for sight-threatening DR and maculopathy and PDR prevalence within 10 years of T1DM diagnosis is very low, confirms this study.
Estimating excess visual loss in people with neovascular age-related macular degeneration during the COVID-19 pandemic
TLDR
A large decrease in nAMD referrals during the first month of COVID-19 lockdown is reported and an important public health message regarding the risk of delayed treatment is provided.
Genetics and genetic testing for age-related macular degeneration
TLDR
The progress made so far in AMD genetics is reviewed and the possible applications for genetic testing are discussed, including growing interest in genetic testing for predicting an individual’s risk of AMD and offering personalised preventive or therapeutic treatments.
A rare penetrant TIMP3 mutation confers relatively late onset choroidal neovascularisation which can mimic age-related macular degeneration
TLDR
This case series suggests the C113G TIMP3 variant may represent a novel highly penetrant mutation causing choroidal neovascularisation of relatively late onset for Sorsby’s fundus dystrophy, mimicking early onset AMD.
From compliment to insult: genetics of the complement system in physiology and disease in the human retina.
TLDR
The complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD are discussed.
Fixed bimonthly aflibercept in naïve and switched neovascular age-related macular degeneration patients: one year outcomes.
TLDR
Fixed bimonthly aflibercept is effective in both treatment-naïve and poorly responsive nvAMD patients, and adopting a fixed dosing regimen can reduce patient burden without compromising on outcomes.
Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
TLDR
Greater exposure to PM2.5 was associated with self-reported age-related macular degeneration and both photoreceptor sublayers and RPE layer thicknesses, and in vivo measures of retinal sublayer thicknesses were associated with differences in retinal layer thickness.
Alcohol Consumption and Incident Cataract Surgery in Two Large UK Cohorts
TLDR
A lower risk of undergoing cataract surgery with low to moderate alcohol consumption is suggested, particularly apparent with wine consumption, and further studies are required to determine whether this association is causal in nature.
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