Associations with covid-19 hospitalisation amongst 406,793 adults: the UK Biobank prospective cohort study
Understanding why these factors confer increased risk of severe covid-19 in the population may help elucidate the underlying mechanisms as well as inform strategy and policy to prevent this disease and its consequences.
Estimating excess visual loss in people with neovascular age-related macular degeneration during the COVID-19 pandemic
A large decrease in nAMD referrals during the first month of COVID-19 lockdown is reported and an important public health message regarding the risk of delayed treatment is provided.
From compliment to insult: genetics of the complement system in physiology and disease in the human retina.
The complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD are discussed.
Genetics and genetic testing for age-related macular degeneration
The progress made so far in AMD genetics is reviewed and the possible applications for genetic testing are discussed, including growing interest in genetic testing for predicting an individual’s risk of AMD and offering personalised preventive or therapeutic treatments.
Quantification of key retinal features in early and late age-related macular degeneration using deep learning.
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
It is suggested that intraocular rather than systemic modulation of complement may prove more effective in relation to age-related macular degeneration and this has important implications for designing novel complement-based AMD therapies.
Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration
This observational analysis assesses the effects of certain lifestyle risk factors on age-related macular degeneration in men and women with a history of smoking, alcohol abuse, or both.
Prevalence of referable, sight-threatening retinopathy in type 1 diabetes and its relationship to diabetes duration and systemic risk factors
T1DM duration is a strong risk factor for sight-threatening DR and maculopathy and PDR prevalence within 10 years of T1DM diagnosis is very low, confirms this study.
A rare penetrant TIMP3 mutation confers relatively late onset choroidal neovascularisation which can mimic age-related macular degeneration
This case series suggests the C113G TIMP3 variant may represent a novel highly penetrant mutation causing choroidal neovascularisation of relatively late onset for Sorsby’s fundus dystrophy, mimicking early onset AMD.
Retinitis pigmentosa and bilateral cystoid macular oedema in a patient heterozygous for the RIM1 mutation previously associated with cone-rod dystrophy 7
The findings were more consistent with a phenotype of retinitis pigmentosa, which could imply that the RIM1 mutation causes diverse retinal dystrophies, or that the previously described CORD7 phenotype resulted from a different variant on the same haplotype.