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Virulence and competitive ability in genetically diverse malaria infections.
- J. D. de Roode, Riccardo Pansini, A. Read
- BiologyProceedings of the National Academy of Sciences…
- 24 May 2005
A strong relationship between parasite virulence and competitive ability is found, so that more virulent strains have a competitive advantage in mixed-strain infections.
Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model
- A. Wargo, S. Huijben, J. D. de Roode, J. Shepherd, A. Read
- BiologyProceedings of the National Academy of Sciences
- 11 December 2007
A substantial competitive release occurred after pyrimethamine curative chemotherapy of acute infections of the rodent malaria Plasmodium chabaudi in laboratory mice, markedly elevating the fitness advantages of drug resistance above those arising from survival alone.
Transmission stage investment of malaria parasites in response to in-host competition
- A. Wargo, J. D. de Roode, S. Huijben, D. Drew, A. Read
- BiologyProceedings of the Royal Society B: Biological…
- 21 August 2007
This study supports much of the current literature, which predicts that conspecific in-host competition will result in a competitive advantage and positive selection for virulent clones and thus the evolution of higher virulence.
CHEMOTHERAPY, WITHIN‐HOST ECOLOGY AND THE FITNESS OF DRUG‐RESISTANT MALARIA PARASITES
- S. Huijben, W. Nelson, A. Wargo, D. Sim, D. Drew, A. Read
- BiologyEvolution; international journal of organic…
- 1 October 2010
The hypothesis that the spread of resistance can be slowed by reducing drug treatment and hence restricting competitive release is tested and raises the question whether the aggressive treatment regimens aimed at complete parasite clearance are the best resistance‐management strategies for humans.
Potential drivers of virulence evolution in aquaculture
The intention is to make aquaculture managers aware of these risks, such that with increased vigilance, they might be able to detect and prevent the emergence and spread of increasingly troublesome pathogen strains in the future.
Viral fitness: definitions, measurement, and current insights
Differential growth of U and M type infectious haematopoietic necrosis virus in a rainbow trout-derived cell line, RTG-2.
It is shown that at a multiplicity of infection (MOI) of 1, a representative U type strain yielded 42-fold less infectious virus than an M type strain in the rainbow trout-derived RTG-2 cell line at 24 h post-infection (p.i).
Manipulation of the Vertebrate Host's Testosterone Does Not Affect Gametocyte Sex Ratio of a Malaria Parasite
The experiment suggests testosterone is not a cue for shaping the sex ratio of gametocytes in P. mexicanum, and this results are related to the evolutionary theory of sex ratios as applied to malaria parasites.
A Missing Dimension in Measures of Vaccination Impacts
It is argued for a shift to a dose-dimension paradigm in infectious disease science and community health, which can guide research on mechanisms of protection, as well as enable model validity across the entire range of transmission intensities.
In Vivo Fitness Associated with High Virulence in a Vertebrate Virus Is a Complex Trait Regulated by Host Entry, Replication, and Shedding
The results suggest that infection cycle fitness is complex and that replication is not the only trait associated with virulence, and that the more virulent of the two genotypes of IHNV the authors used had advantages in all of the traits quantified.