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Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs
The in-house IIIM natural product repository of 302 small molecules was screened for their ability to inhibit P-glycoprotein (Pgp) in Pgp-overexpressing human adenocarcinoma LS-180 cells. TheExpand
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Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.
The screening of IIIM natural products repository for P-gp modulatory activity in P-gp over-expressing human adenocarcinoma LS-180 cells led to the identification of 7 natural products viz.Expand
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Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents.
Meridianins are a group of marine-derived indole alkaloids which are reported to possess kinase inhibitory activities. In the present Letter, we report synthesis of N1-substituted and C-ring modifiedExpand
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3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity.
3-((Quinolin-4-yl)methylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide (OSI-930, 1) is a potent inhibitor of c-kit and VEGFR2, currently under phase I clinical trials in patients withExpand
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Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump.
Polysubstituted pyrrole natural products, lamellarins, are known to overcome multi-drug resistance in cancer via the inhibition of p-glycoprotein (P-gp) and breast cancer resistance protein (BCRP)Expand
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Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells.
The ethyl acetate extract from the fermentation broth of an actinomycete strain, identified as Streptomyces scabrisporus isolated from soil of Kashmir Himalayas - India, exhibited significantExpand
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The amino analogue of &bgr;‐boswellic acid efficiently attenuates the release of pro‐inflammatory mediators than its parent compound through the suppression of NF‐&kgr;B/I&kgr;B&agr; signalling axis
Graphical abstract Figure. No Caption available. HighlightsComparative study of &bgr;‐boswellic acid and its analogue, BA‐25 for anti‐inflammatory potential.BA‐25 strongly inhibits the expressionExpand
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Comparative Physicochemical Limnology of three lakes of Kashmir Himalaya
In the present paper an effort has been made to evaluate the tropic status of three lakes viz; Dal, Nilnag and Sheshnag on the basis of physicochemical parameters criterion. It has been observed thatExpand
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Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease
Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied withExpand
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Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway
ABSTRACT Imbalance in production and clearance of amyloid beta (Aβ) is the primary reason for its deposition in Alzheimer disease. Macroautophagy/autophagy is one of the important mechanisms forExpand
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