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Effects of Topiramate on Sodium‐Dependent Action‐Potential Firing by Mouse Spinal Cord Neurons in Cell Culture
Purpose: The effects of topiramate (TPM) on sodium‐dependent action potentials were studied by using cultured mouse spinal cord neurons.
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Oxcarbazepine: Mechanisms of Action
Summary: The antiepileptic drug (AED) oxcarbazepine (OCBZ) and its rapidly formed 10‐monohydroxy metabolite (MHD) protect against electroshock‐induced tonic hindlimb extension in rodents (ED50 14–21Expand
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A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents
Objective: This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. Method: A total of 116 outpatients 7 to 18 yearsExpand
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Measurement and analysis of static magnetic fields that block action potentials in cultured neurons.
To characterize the properties of static magnetic fields on firing of action potentials (AP) by sensory neurons in cell culture, we developed a mathematical formalism based on the expression for theExpand
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CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury.
CM101, an antiangiogenic polysaccharide derived from group B streptococcus, was administered by i.v. injection 1 hr post-spinal-cord crush injury in an effort to prevent inflammatory angiogenesis andExpand
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Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Common antiepileptic drugs and agents affecting different neurotransmitter systems were studied against aminophylline (280 mg/kg i.p.)-induced convulsions in mice. All drugs and agents wereExpand
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Blockade of sensory neuron action potentials by a static magnetic field in the 10 mT range.
To characterize the inhibitory effect of a static magnetic field, action potentials (AP) were elicited by intracellular application of 1 ms depolarizing current pulses of constant amplitude to theExpand
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Effect of aminophylline upon the protective activity of common antiepileptic drugs and their plasma levels in mice
Aminophylline (50 mg/kg) decreased the protective efficacy of carbamazepine (20 mg/kg), diphenylhydantoin (8-12 mg/kg), phenobarbital (20 and 25 mg/kg), and valproate (250 and 300 mg/kg) againstExpand
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Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures.
The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations dependedExpand
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Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat.
Male Sprague-Dawley rats injected sc with a single sublethal dose of the organophosphate nerve agent, soman (100 micrograms/kg), had motor limbic seizures within 5-15 min. Pretreatment with a singleExpand
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