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Structure and function of efflux pumps that confer resistance to drugs.
A review of advances that have been made in understanding the structure and function of drug efflux pumps and how conformational changes in these proteins are coupled to substrate translocation is reported.
The kinetics of glucose transport in human red blood cells.
The Crystal Structure of the Outer Membrane Protein VceC from the Bacterial Pathogen Vibrio cholerae at 1.8 Å Resolution*
The analyses of the external surfaces of VceC and other channel proteins suggest that different classes of efflux pumps have distinct architectures, and the implications of these findings for mechanisms of drug and protein export are discussed.
The pathobiology of Paracoccidioides brasiliensis.
An arsenic metallochaperone for an arsenic detoxification pump
- Yung-feng Lin, A. Walmsley, B. Rosen
- Engineering, BiologyProceedings of the National Academy of Sciences
- 17 October 2006
Environmental arsenic is a world-wide health issue, making it imperative for us to understand mechanisms of metalloid uptake and detoxification. The predominant intracellular form is the highly…
Elucidation of the hrp Clusters of Xanthomonas oryzae pv. oryzicola That Control the Hypersensitive Response in Nonhost Tobacco and Pathogenicity in Susceptible Host Rice
- L. Zou, Xingsheng Wang, Gongyou Chen
- Medicine, BiologyApplied and Environmental Microbiology
- 1 September 2006
It is found that an hrpF mutant had lost the ability to elicit the HR in tobacco and pathogenicity in adult rice plants but still caused water-soaking symptoms in rice seedlings and that Hpa1 is an HR elicitor in nonhost tobacco whose expression is controlled by an hrP regulator, HrpX.
TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction…
Here we identify an 11-residue helical module in the unique N-terminal region of the cyclic AMP-specific phosphodiesterase PDE4A1 that determines association with phospholipid bilayers and shows a…
The N-terminal Region of the Prion Protein Ectodomain Contains a Lipid Raft Targeting Determinant*
Data indicate that the N-terminal region of PrP acts as a cellular raft targeting determinant and that residues 23–90 of Prp represent the first proteinaceous raft targeting signal within the ectodomain of a GPI-anchored protein.
Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo‐66 receptor
The data indicate that NgR, NgRH1 and NgRH2 constitute a novel receptor protein family, which may play related roles within the CNS.
Intracellular Retention of Procollagen within the Endoplasmic Reticulum Is Mediated by Prolyl 4-Hydroxylase*
It is shown that the major protein binding to procollagen during its biosynthesis is prolyl 4-hydroxylase, and no binding to other ER resident proteins including Hsp47 was detected, demonstrating that this enzyme can recognize and retain unfolded Procollagen chains and can release these chains for further transport once they have folded correctly.