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Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect.
Observational studies often provide the only available information about treatment effects. Control of confounding, however, remains challenging. The authors compared five methods for evaluating theExpand
Obesity and knee osteoarthritis. The Framingham Study.
Obesity at examination 1 was associated with the risk of developing both symptomatic and asymptomatic osteoarthritis, and was strongest for persons with severest radiographic disease. Expand
Concepts of interaction.
It is proposed that synergy (or its negative counterpart, antagonism) between two or more causes of disease ought to be evaluated in reference to a specific yardstick, with effect defined as excess risk. Expand
Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization.
The incidence of symptomatic hand, hip, and knee OA increased with age, and women had higher rates than men, especially after age 50, and a leveling off or decline occurred for both groups around the age of 80. Expand
Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity.
The impact of vaccination with MCC vaccine on the prevalence of carriage of group C meningococci was consistent with herd immunity, and the high impact on the carriage of ST-11 complex serogroup C could be attributed to high levels of capsule expression. Expand
Ganciclovir and Acyclovir Reduce the Risk of Post‐Transplant Lymphoproliferative Disorder in Renal Transplant Recipients
Anti‐viral therapy appears to play a role in reducing the risk of PTLD in renal transplant patients, and ganciclovir may be more potent than acyclovir. Expand
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
It is suggested that a sizable proportion of cases of APV with high titers of anti-MPO antibodies are drug-associated, especially following exposure to hydralazine or propylthiouracil. Expand
Mortality in current and former users of clozapine
Clozapine appears to reduce mortality in severe schizophrenics, mostly by decreasing suicide rates, as compared with other antipsychotic drugs. Expand
Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee.
It is found that body weight was a predictor of incident osteoarthritis of the hand, hip, and knee and the results suggest that obesity is associated with the development of incident arthritis at all joints studied. Expand
Folic acid antagonists during pregnancy and the risk of birth defects.
Folic acid antagonists, which include such common drugs as trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase the risk not only of neural-tube defects, but also of cardiovascular defects, oral clefts, and urinary tract defects. Expand