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Mucosal capillary thrombi in rectal biopsies
Thrombi were observed in 8/13 cases of ulcerative colitis, 4/10 cases of Crohn's disease, 1/3 cases of unspecified inflammatory bowel disease and 5/20 cases of self‐limited colitis; the presence of capillary thrombi was not related to the severity of inflammation, but none of the control biopsies showed capillary Thrombi. Expand
Spontaneous Mucosal Lymphocyte Cytokine Profiles in Children with Autism and Gastrointestinal Symptoms: Mucosal Immune Activation and Reduced Counter Regulatory Interleukin-10
There is a consistent profile of CD3+ lymphocyte cytokines in the small and large intestinal mucosa of these ASD children, involving increased pro-inflammatory and decreased regulatory activities. Expand
1 were brought to the attention of senior editorial staff of the journal. The allegations are: 1. That, contrary to a statement in the Lancet paper, ethics approval for the investigations conductedExpand
Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders
No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. Expand
Enterocolitis in children with developmental disorders
A new variant of inflammatory bowel disease is present in this group of children with developmental disorders, and scores of frequency and severity of inflammation were significantly greater in both affected children and those with UC, compared with controls. Expand
Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism.
Immunohistochemistry confirms a distinct lymphocytic colitis in autistic spectrum disorders in which the epithelium appears particularly affected, consistent with increasing evidence for gut epithelial dysfunction in autism. Expand
Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Extensive Mucosal Immunopathology
The data provide further evidence of a pan-enteric mucosal immunopathology in children with regressive autism that is apparently distinct from other inflammatory bowel diseases. Expand
Crohn's disease after in-utero measles virus exposure
Exposure of mothers to measles virus in utero is a risk factor for Crohn's disease in their children, and exposure at this time may lead to persistent infection, or modify the response to infection in later life, leading to persistence of measles virus. Expand
MMR vaccination and autism
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children (Retracted article. See vol 375, pg 445, 2010)
Background We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder.Methods 12 children (mean age 6 years [range 3-10], 11 boys) were referredExpand