• Publications
  • Influence
A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells
At mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash aExpand
  • 460
  • 64
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.
Prohibitins comprise an evolutionarily conserved and ubiquitously expressed family of membrane proteins with poorly described functions. Large assemblies of PHB1 and PHB2 subunits are localized inExpand
  • 387
  • 45
  • PDF
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Influx of macrophages plays a crucial role in tissue repair. However, the precise function of macrophages during the healing response has remained a subject of debate due to their functionalExpand
  • 712
  • 38
Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction
Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution atExpand
  • 854
  • 35
  • PDF
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
A new system for lineage ablation is based on transgenic expression of a diphtheria toxin receptor (DTR) in mouse cells and application of diphtheria toxin (DT). To streamline this approach, weExpand
  • 592
  • 35
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
Although microglial activation occurs in inflammatory, degenerative and neoplastic central nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this question by generatingExpand
  • 649
  • 34
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
A prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals forExpand
  • 323
  • 28
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice.
The clear association of Th17 cells with autoimmune pathogenicity implicates Th17 cytokines as critical mediators of chronic autoimmune diseases such as EAE. To study the impact of IL-17A on CNSExpand
  • 392
  • 25
  • PDF
Agouti-related peptide–expressing neurons are mandatory for feeding
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless,Expand
  • 603
  • 20
Cellular mechanisms of IL‐17‐induced blood‐brain barrier disruption
Recently T‐helper 17 (Th17) cells were demonstrated to disrupt the blood‐brain barrier (BBB) by the action of IL‐17A. The aim of the present study was to examine the mechanisms that underlieExpand
  • 291
  • 20