Robustness and Evolvability in Living Systems
- A. Wagner
- Biology
- 25 July 2005
This book discusses robustness in Natural Systems and Self-Organization, as well as Robustness in Man-made Systems, and seven open questions for Systems Biology.
Robustness and evolvability: a paradox resolved
- A. Wagner
- BiologyProceedings of the Royal Society B: Biological…
- 7 January 2008
It is confirmed that genotype (sequence) robustness and evolvability share an antagonistic relationship, which means that finite populations of sequences with a robust phenotype can access large amounts of phenotypic variation while spreading through a neutral network.
Energy constraints on the evolution of gene expression.
- A. Wagner
- BiologyMolecular biology and evolution
- 1 June 2005
The energy cost of changes in gene expression for several thousand genes in the yeast Saccharomyces cerevisiae is estimated, finding that the evolution of transcription and translation rates is not an evolutionarily neutral process and is under active selection opposing them.
The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes.
- A. Wagner
- BiologyMolecular biology and evolution
- 1 July 2001
The structure and evolution of the protein interaction network of the yeast Saccharomyces cerevisiae is analyzed and it is shown that the persistence of redundant interaction partners is the exception rather than the rule.
Innovation and robustness in complex regulatory gene networks
- S. Ciliberti, O. Martin, A. Wagner
- BiologyProceedings of the National Academy of Sciences
- 21 August 2007
It is concluded that long-term innovation in gene expression patterns can only emerge in the presence of the robustness caused by connected genotype graphs.
Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology
- S. Ciliberti, O. Martin, A. Wagner
- BiologyPLoS Comput. Biol.
- 1 February 2007
A model of transcriptional regulation networks, in which millions of different network topologies are explored, shows that connectedness and evolvability of robust networks may be a general organizational principle of biological networks.
DOES EVOLUTIONARY PLASTICITY EVOLVE?
- A. Wagner
- BiologyEvolution; international journal of organic…
- 1 June 1996
It is discussed that only epistatic (nonlinear) gene interactions can cause change in epigenetic stability, and evidence from paleontology, molecular evolution, development, and genetics, consistent with the existence of variation in epigenetics stability is discussed.
Growthcurver: an R package for obtaining interpretable metrics from microbial growth curves
- K. Sprouffske, A. Wagner
- MedicineBMC Bioinformatics
- 19 April 2016
Growthcurver summarizes the growth characteristics of microbial growth curve experiments conducted in a plate reader and is an easy-to-use R package available for installation from the Comprehensive R Archive Network (CRAN).
Robustness, evolvability, and neutrality
- A. Wagner
- BiologyFEBS Letters
- 21 March 2005
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