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Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates
Measles virus (MV) is highly infectious, and has long been thought to enter the host by infecting epithelial cells of the respiratory tract. However, epithelial cells do not express signalingExpand
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Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation.
Carbohydrate-specific signalling through DC-SIGN provides dendritic cells with plasticity to tailor immunity to the nature of invading microbes. Here we demonstrate that recognition ofExpand
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Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
The cytosolic sensor MDA5 is crucial for antiviral innate immune defense against various RNA viruses including measles virus; as such, many viruses have evolved strategies to antagonize the antiviralExpand
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Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.
Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV and induceExpand
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A Prominent Role for DC-SIGN+ Dendritic Cells in Initiation and Dissemination of Measles Virus Infection in Non-Human Primates
Measles virus (MV) is a highly contagious virus that is transmitted by aerosols. During systemic infection, CD150+ T and B lymphocytes in blood and lymphoid tissues are the main cells infected byExpand
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Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission
BackgroundSexual transmission is the main route of HIV-1 infection and the CCR5-using (R5) HIV-1 is predominantly transmitted, even though CXCR4-using (X4) HIV-1 is often abundant in chronic HIV-1Expand
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Pattern Recognition Receptors in HIV Transmission
Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells playExpand
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RIG-I-like receptors and intracellular Toll-like receptors in antiviral immunity
Viral recognition by pattern recognition receptors is a crucial step in antiviral immunity. Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) represent two classes of nucleic acid-sensingExpand
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UvA-DARE ( Digital Academic Repository ) Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates
Measles virus (MV) is highly infectious, and has long been thought to enter the host by infecting epithelial cells of the respiratory tract. However, epithelial cells do not express signalingExpand
5 DIFFERENTIAL EXPRESSION OF DC-SIGN FOLLOWING TOLL-LIKE RECEPTOR AND RIG-ILIKE RECEPTOR ACTIVATION
Dendritic cell (DC) maturation is crucial for activation of adaptive immune responses. Central to DC activation is pathogen recognition by pattern recognition receptors, such as Toll-like receptorsExpand