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The comparative toxicology of ethyl- and methylmercury
Weight loss relative to the expected body weight and renal damage was higher in ethylmercury-treated rats than in rats given equimolar doses of methylcury, and in renotoxicity the renal concentration of inorganic mercury seems to be more important than the concentration of organic or total mercury. Expand
1,3‐Dinitrobenzene‐induced encephalopathy in rats shows hallmarks of multiple mechanisms, including ‘cell reprograming’, ‘cerebral haemorrhage’ and ‘plagiarism’. Expand
The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat.
Treatment of rats with trimethyltin provides a chronic preparation with consistent lesions in the hippocampus of use in other behavioral and neuroanatomic studies. Expand
Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations.
Ulastructural examination showed that the majority of microvacuoles in the neuronal cytoplasm correspond to swollen mitochondria, and the evolution of ischaemic cell change with an without incrustations appeared to occur by a progressive condensation of the cy toplasm between all intraneuronal dilated spaces, sometimes accompanied by shrinkage of the swollen mitochondaria. Expand
The threshold and neuropathology of cerebral "anoxic-ischemic" cell change.
It is essential to emphasize at the outset that "anoxic-ischemic" cell change is not, as the term suggests, a neuronal alteration due to anoxiaischemia alone. The term anoxia-is-chemia was introducedExpand
Cyanide intoxication in Macaca mulatta Physiological and neuropathological aspects
There is no evidence for hypoxic neuronal damage of purely histotoxic type in lightly anaesthetised and spontaneously breathing M. mulatta. Expand
Selective degeneration of cerebellar cortical neurons caused by cycad neurotoxin, L‐β‐methylaminoalanine (L‐BMAA), in rats
The present finding of selective cerebellar neuron damage may not conflict with the earlier findings of others, but the results suggest that L‐BMAA has unusual glutamate receptor binding properties. Expand
The neurotoxicity of trimethyltin chloride in hamsters, gerbils and marmosets
TMT does not bind to human haemoglobin and thus the predicted lethal dose for humans may be about 3 mg kg−1 (15.1 μmolkg−1), while the dose required to produce neuronal damage could well be less. Expand
The origin of lipid phagocytes in the central nervous system: II. The adventitia of blood vessels
The source of the lipid phagocytes that occupy a cerebral infarct has been determined by light and electron microscopy in the brains of rodents and by light microscopy only in the brains of primates.Expand