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Regional cerebral blood flow as assessed by principal component analysis and (99m)Tc-HMPAO SPET in healthy subjects at rest: normal distribution and effect of age and gender.
The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects forExpand
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Regional cerebral blood flow as assessed by principal component analysis and 99mTc-HMPAO SPET in healthy subjects at rest: normal distribution and effect of age and gender
Abstract. The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjectsExpand
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Prolonged Inhibition of Glutamate Reuptake Down‐Regulates NMDA Receptor Functions in Cultured Cerebellar Granule Cells
Abstract: In the present study, we have examined the effects of prolonged (up to 72 h) inhibition of high‐affinity glutamate reuptake by L‐trans‐pyrrolidine‐2,4‐dicarboxylate (PDC; 100 γM) onExpand
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Differences in resting state regional cerebral blood flow assessed with 99mTc-HMPAO SPECT and brain atlas matching between depressed patients with and without tinnitus
An increased occurrence of major depressive disorder has been reported in tinnitus patients, and of tinnitus in depressive patients. Involvement of several Brodmann areas (BAs) has been reported inExpand
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Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors.
The relative affinities of nortriptyline (NT) and its 10-hydroxymetabolites to rat brain muscarinic acetylcholine receptors have been determined by competition with 3H-quinuclidinyl benzilateExpand
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Therapeutic effects of serotonin uptake inhibitors in depression.
Depression has been associated with a disturbance in serotonin function as reflected in platelet uptake of the transmitter as well as in CSF levels of its major metabolite, 5-hydroxyindoleacetic acidExpand
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Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3 H‐imipramine binding and serotonin uptake and concentration in major depressive disorder
In an open study of 12 inpatients who met the DSM‐III criteria for a major depressive episode, the effects of clomipramine (CI) on the monoamine metabolites 5‐hydroxyindoleacetic acid (5‐HIAA),Expand
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Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder.
The effects of four antidepressant treatments on platelet tritiated imipramine binding have been studied in 51 hospitalized patients with severe major depressive disorder. There was an increase inExpand
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Extradural compression of sensorimotor cortex: a useful model for studies on ischemic brain damage and neuroprotection.
Behavioral and morphological changes were examined for up to 9 days after moderate cerebral ischemia caused by slow compression of a specific brain area in the sensorimotor cortex of Sprague-DawleyExpand
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