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The stimulating action of ACTH and related polypeptides on the spontaneous rhythm of isolated heart muscle cells in vitro
ACTH and α-MSH increase the rate of spontaneous pulsation of single isolated myoblasts cultured from the chick embryo heart and the accelerator action of ACTH on cardiac cells is reduced when the ACTH is trented with periodate and boron hydride.
[Antiaccelerative and antiarrhythmic effect of veratramin on myocardial cells in culture].
The authors conclude that the chronotropic effect of veratramin is not associated with the cell receptor mechanisms but is due to its effect on the transport of ions through the cell membrane, which is a responsible process in the generation of impulses.