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Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin. The localization in bone and theExpand
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High resolution analysis of interphase chromosome domains.
Chromosome territories need to be well defined at high resolution before functional aspects of chromosome organization in interphase can be explored. To visualize chromosomes by electron microscopyExpand
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Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation
Sclerostin is an osteocyte‐derived negative regulator of bone formation. It inhibits BMP‐stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead,Expand
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Stress response symptoms in adolescent and young adult children of parents diagnosed with cancer.
The aim of this study was to assess stress response symptoms in children of parents diagnosed with cancer 1-5 year prior to study entry. The impact of event scale was used to measure stress responseExpand
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Psychosocial Consequences for Children of a Parent With Cancer: A Pilot Study
When cancer is diagnosed in a parent, this may also have consequences for the children. The purpose of this pilot study was to gain more insight into the psychosocial consequences for children of aExpand
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Structure and expression of the human calcitonin/CGRP genes
Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene‐related peptide (hCGRP‐II) [(1985) FEBS Lett. 183, 403‐407]. In this report we describe the isolation andExpand
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Spatial distributions of early and late replicating chromatin in interphase chromosome territories.
The surface area of chromosome territories has been suggested as a preferred site for genes, specific RNAs, and accumulations of splicing factors. Here, we investigated the localization of sites ofExpand
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Emotional and behavioral problems in children of parents recently diagnosed with cancer: A longitudinal study
This study examines the prevalence of problems in children within four months after a parent's cancer diagnosis (T1) and six (T2) and twelve months (T3) afterwards. Sixty-nine ill parents and 57Expand
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Both Complement and IgG Fc Receptors Are Required for Development of Attenuated Antiglomerular Basement Membrane Nephritis in Mice1
To elucidate the mechanisms of glomerulonephritis, including Goodpasture’s syndrome, mouse models are used that use heterologous Abs against the glomerular basement membrane (GBM) with or withoutExpand
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Chromosomes as well as chromosomal subdomains constitute distinct units in interphase nuclei.
Fluorescence in situ hybridization has demonstrated that chromosomes form individual territories in interphase nuclei. However, this technique is not suitable to determine whether territories areExpand
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