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The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms.
The paper outlines a 2-tier approach for wide-scale biomonitoring programmes. To obtain a high level of standardization, we suggest the use of caged organisms (mussels or fish). An "early warning",Expand
A simple spectrophotometric method for metallothionein evaluation in marine organisms: an application to Mediterranean and Antarctic molluscs
Abstract A spectrophotometric method to evaluate the concentration of metallothioneins in the tissues of marine organisms has been developed. Metallothionein concentration was evaluated utilizing aExpand
The use of biomarkers to assess the impact of pollution in coastal environments of the Iberian Peninsula: a practical approach.
Within the frame of the 2nd Iberian Congress of Environmental Contamination and Toxicology (University of the Basque Country, Leioa, June 1998) a workshop was held about the use of biomarkers inExpand
Mechanisms of heavy metal cation homeostasis in marine invertebrates
Abstract 1. The main mechanisms involved in heavy metal cation homeostasis in marine invertebrate cells are described. 2. Metallothioneins are probably the most important soluble compounds involvedExpand
Heavy metals and glutathione metabolism in mussel tissues
Abstract Data are presented on the tissue glutathione content and on the activity of two of the main enzymes involved in GSH metabolism (γ-glutamyl-cysteine synthetase (GCS), GSH transferase (GST))Expand
Heavy metal effects on lipid peroxidation in the tissues of mytilus gallopro vincialis lam.
Abstract 1. The effects of heavy metals on lipid peroxidation in the gills and digestive gland of mussels exposed for six days to Cu 2+ , Cd 2+ or Zn 2+ (40 μg/l/animal) were investigated. 2. In theExpand
Antioxidant role of metallothioneins: a comparative overview.
Metallothioneins (MTs) are sulfhydryl-rich proteins binding essential and non-essential heavy metals. MTs display in vitro oxyradical scavenging capacity, suggesting that they may specificallyExpand
Genotoxicity biomarkers in the assessment of heavy metal effects in mussels: Experimental studies
Heavy metals are stable and persistent environmental contaminants. The range of metal concentrations is generally below acute thresholds in coastal areas, where recognition of chronic sublethalExpand
Quantitative PCR analysis of two molluscan metallothionein genes unveils differential expression and regulation.
The mRNA levels of two components of the mussel (Mytilus galloprovincialis) metallothionein (MT) gene families, MT10 and MT20, were evaluated using real-time quantitative-PCR and Sybr Green IExpand
Exposure to elevated temperatures and hydrogen peroxide elicits oxidative stress and antioxidant response in the Antarctic intertidal limpet Nacella concinna
This study deals with the occurrence of oxidative stress and antioxidant response in the Antarctic intertidal limpet Nacella concinna, as an effect of temperature increments and H2O2 exposure underExpand
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