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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in western countries, with a median survival of 6 months and an extremely low percentage of long-term surviving patients. KRASExpand
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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
Histone deacetylases (HDACs) regulate transcription and specific cellular functions, such as tumor suppression by p53, and are frequently altered in cancer. Inhibitors of HDACs (HDACIs) possessExpand
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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Rare cells with the properties of stem cells are integral to the development and perpetuation of leukaemias. A defining characteristic of stem cells is their capacity to self-renew, which is markedlyExpand
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Gorham‐Stout Syndrome: A Monocyte‐Mediated Cytokine Propelled Disease
We studied the biological features and the immunophenotype of a cell culture established from the lesion of soft tissues of a woman affected by Gorham‐Stout syndrome. We found that these cellsExpand
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DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functionsExpand
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Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined
The ability of advanced-generation lentiviral vectors to transfer the green fluorescent protein (GFP) gene into human hematopoietic stem cells (HSCs) was studied in culture conditions that allowedExpand
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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Arozena, AA; Adachi, H; Adams, CM; Adams, PD; Adeli, K; Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello,Expand
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ERRATUM: Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
Nat. Med. 11, 71–76 (2005) In Fig. 2a, the second and fourth graphs in the lower row should be marked Tnfrsf10b and Tnfrsf6, respectively. In Fig. 2b, the gene symbol Tp53 should read Tp53−/−. InExpand
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Vasculogenic potential of long term repopulating cord blood progenitors
In the adult, involvement of bone marrow‐derived circulating endothelial progenitor cells (EPCs) in tissue revascularization (vasculogenesis) and the cooperation of hematopoietic cell subsets inExpand
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