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Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells
- L. Berkovich, G. Earon, I. Ron, A. Rimmon, A. Vexler, S. Lev-Ari
- BMC Complementary and Alternative Medicine
- 19 August 2013
BackgroundFewer than 6% patients with adenocarcinoma of the pancreas live up to five years after diagnosis. Chemotherapy is currently the standard treatment, however, these tumors often develop drug… Expand
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but mechanisms underlying their oncogenic potential… Expand
Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.
BACKGROUND Several studies suggested that curcumin inhibits growth of malignant cells via inhibition of cyclooxygenase-2 (COX-2) activity. Other studies indicated that epidermal growth factor… Expand
ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti‐cancer therapy
Clinical and experimental data suggest that ErbB‐4, a member of the epidermal growth factor receptor family, may have a role in cancer progression and response to treatment. We found recently, using… Expand
Chronic graft-versus-host disease treated with UVB phototherapy
- C. Enk, S. Elad, A. Vexler, J. Kapelushnik, R. Gorodetsky, M. Kirschbaum
- Bone Marrow Transplantation
- 1 December 1998
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic bone marrow transplantation. Immunosuppressive treatment regimens carry the potential of causing severe morbidity and… Expand
Evaluation of skin viscoelasticity and anisotropy by measurement of speed of shear wave propagation with viscoelasticity skin analyzer.
- A. Vexler, I. Polyansky, R. Gorodetsky
- Medicine, Biology
- The Journal of investigative dermatology
- 1 November 1999
Skin viscoelasticity was evaluated by a fast, noninvasive assay based on the measurement of the speed of elastic shear wave propagation in the skin by a new portable and user-friendly viscoelasticity… Expand
Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer.
An increasing number of studies indicate that reduced DNA-repair capacity is associated with increased cancer risk. Using a functional assay for the removal of the oxidative DNA lesion 8-oxoguanine… Expand
Curcumin Augments Gemcitabine Cytotoxic Effect on Pancreatic Adenocarcinoma Cell Lines
Background and aim: Gemcitabine, the first-line agent in pancreatic adenocarcinoma, has shown limited clinical benefit. Cyclooxygenase-2 (COX-2) represent one of the most promising targets for cancer… Expand
Combination of cisplatin and radiation in cell culture: Effect of duration of exposure to drug and timing of irradiation
- R. Gorodetsky, F. Levy‐Agababa, X. Mou, A. Vexler
- International journal of cancer
- 9 February 1998
Responses to the combination of cisplatin (CDDP) and radiation in experimental and clinical studies have been reported to vary from high radiosensitization to clear sub‐additivity. We examined the… Expand
Low pH value of pericellular medium as a factor limiting cell proliferation in dense cultures.
- V. Akatov, É. Lezhnev, A. Vexler, L. N. Kublik
- Biology, Medicine
- Experimental cell research
- 1 October 1985
An attempt was made to determine the role of metabolic acidification of pericellular medium in regulating cell proliferation. A method of measuring the pH of pericellular medium at a distance… Expand