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Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid
TLDR
The detection times depend mainly on the dose and sensitivity of the method used, the preparation and route of administration, the duration of use, the matrix that is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and the interindividual variation in metabolic and renal clearance. Expand
Risk of injury by driving with alcohol and other drugs
TLDR
Assessment of the risk of driving with alcohol, illicit drugs and medicines in various European countries and the study on relative risk of serious injury/fatality while positive for psychoactive substances finds that Finland, Norway, Sweden and Portugal are at risk. Expand
Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material.
TLDR
A simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material and was validated following an approach using accuracy profiles based on beta-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty. Expand
Prevalence and Risk of Injury in Europe by Driving with Alcohol, Illicit Drugs and Medicines
TLDR
Combined alcohol/drug use and multiple drug use were far more common in accident-involved drivers than in drivers in traffic, and the prevalence of other drugs was highest in the driving population in southern Europe with THC as most common, whereas benzodiazepines dominated in the northern countries of Europe. Expand
Effects of alcohol (BAC 0.5‰) and ecstasy (MDMA 100 mg) on simulated driving performance and traffic safety
TLDR
The dissociation between subjective perceptions and objective performance decrements are important notions for traffic safety since this may affect a driver’s judgement of whether or not it is safe to drive. Expand
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of docetaxel and paclitaxel in human plasma and oral fluid.
TLDR
A sensitive and robust method was obtained, which fulfilled all validation criteria, and accuracy varied from 91.3 to 103.6%, and imprecision did not exceed 12.7% for all analytes in plasma and oral fluid. Expand
A Case-Control Study Estimating Accident Risk for Alcohol, Medicines and Illegal Drugs
TLDR
Alcohol and alcohol-drug combinations are by far the most prevalent substances in drivers and subsequently pose the largest risk in traffic, both in terms of risk and scope. Expand
Validated method for the simultaneous determination of Delta9-THC and Delta9-THC-COOH in oral fluid, urine and whole blood using solid-phase extraction and liquid chromatography-mass spectrometry
TLDR
The LC-MS technique can be regarded as an alternative method to GC-MS for the confirmation of positive immunoassay test results, and can be used as a suitable analytical tool for the quantification of THC and THC-COOH in oral fluid, urine and/or blood samples. Expand
Detection Time of Drugs of Abuse in Urine
TLDR
Investigation times for detection of drugs in urine vary depending on dose and route of administration, metabolism and characteristics of the screening and confirmation assays, particularly for heroin and designer amphetamines. Expand
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