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Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
The pharmacokinetics of three beta adrenoceptor blocking drugs atenolol, metoprolol, propranolol and of the model drug antipyrine were studied in 3-, 12- and 24-month-old rats. Alpha-1-acidExpand
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Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate.
A sensitive high-performance liquid chromatographic method for the determination of the enantiomers of atenolol in rat plasma has been developed. Racemic atenolol and practolol (internal standard)Expand
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The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat.
The influence of aging on the pharmacokinetics and the tissue distribution of (R)- and of (S)-propranolol was studied in 3-, 12-, and 24-month-old rats. After both iv and oral administration ofExpand
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Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat.
After i.v. administration of racemic metoprolol in the rat, the plasma concentrations of (R)- and (S)-metoprolol were comparable, and no differences in pharmacokinetic parameters between the twoExpand
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Stereoselective pharmacokinetics of atenolol in the rat: Influence of aging and of renal failure
The pharmacokinetics of R- and S-atenolol after intravenous administration of racemic atenolol were studied in 3-, 12- and 24-month-old rats and in 3-month-old rats with renal failure induced byExpand
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Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.
The influence of i.v. administration of 10 micrograms/kg recombinant human interleukin-1 beta (rhIL-1 beta), a putative mediator of inflammation, on the pharmacokinetics and metabolism of theExpand
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High-performance liquid chromatographic method for the simultaneous determination of R-(-)- and S-(+)-hexobarbital in rat plasma.
The enantiospecific determination of R- and S-hexobarbital in rat plasma is described. The method involves liquid-liquid extraction of racemic hexobarbital from plasma, separation of theExpand
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The effect of different calcium antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes
Summary— The influence of the dihydropyridine calcium entry blockers nicardipine, amlodipine, nifedipine, isradipine and of the dihydropyridine calcium entry promotor BAY K 8644 on the disappearanceExpand
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Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat
The influence of age on stereoselective pharmacokinetics and in vitro metabolism of R- and S-hexobarbital was studied in the rat. After intravenous administration of the racemate, the plasmaExpand
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On the radiochemical quality control of [123I] sodium iodide for thyroid scanning.
Use of [123I]sodium iodide of too high specific activity in preparations for the diagnosis of disorders of the thyroid can lead to erroneous values for protein bound iodine and 24 h iodine uptake inExpand
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