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Neuropathology provides clues to the pathophysiology of Gaucher disease.
To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and dementia), threeExpand
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Stress Impairs 5-HT2A Receptor-Mediated Serotonergic Facilitation of GABA Release in Juvenile Rat Basolateral Amygdala
The occurrence of stress and anxiety disorders has been closely associated with alterations of the amygdala GABAergic system. In these disorders, dysregulation of the serotonergic system, a veryExpand
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Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
Glucose metabolism in nervous tissue has been proposed to occur in a compartmentalized manner with astrocytes contributing largely to glycolysis and neurons being the primary site of glucoseExpand
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Comparison of Medical and Consumer Wireless EEG Systems for Use in Clinical Trials
Objectives: To compare quantitative EEG signal and test-retest reliability of medical grade and consumer EEG systems. Methods: Resting state EEG was acquired by two medical grade (B-Alert, Enobio)Expand
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Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial
Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trialExpand
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Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study
Traumatic brain injury (TBI) triggers many secondary changes in tissue biology, which ultimately determine the extent of injury and clinical outcome. Hyaluronan [hyaluronic acid (HA)] is a protectiveExpand
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Photodynamic Tumor Therapy: Mitochondrial Benzodiazepine Receptors as a Therapeutic Target
BackgroundPhotodynamic therapy employs photosensitive agents such as porphyrins to treat a variety of tumors accessible to light-emitting probes. This approach capitalizes on the selective retentionExpand
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Oxygen-sensing in tumors
  • A. Verma
  • Medicine, Biology
  • Current opinion in clinical nutrition and…
  • 1 July 2006
Purpose of reviewTumor hypoxia induces cancer cell treatment resistance, angiogenesis, invasiveness, and overall poor clinical outcome. Cellular adaptations to hypoxia are largely driven byExpand
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Optimizing Central Nervous System Drug Development Using Molecular Imaging
Advances in multimodality fusion imaging technologies promise to accelerate the understanding of the systems biology of disease and help in the development of new therapeutics. The use of molecularExpand
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Skeletal muscle oxidative capacity in amyotrophic lateral sclerosis
Introduction: Mitochondrial dysfunction in the motor neuron has been suspected in amyotrophic lateral sclerosis (ALS). If mitochondrial abnormalities are also found in skeletal muscle, assessingExpand
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