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Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus
TLDR
Analysis of insulin resistance at 11 years in a multivariate logistic regression revealed that childhood obesity and the combination of LGA status and maternal GDM were associated with insulin resistance, with odds ratios of 4.3 and 4.4 (95% CI: 1.5–74.4), respectively.
Insulin resistance syndrome in women with prior history of gestational diabetes mellitus.
TLDR
It is concluded that obesity and GDM in a prior pregnancy are significant risk factors for developing IRS over time and early detection of markers of IRS is vital for possible prevention of type 2 diabetes and cardiovascular adverse events in women.
Relative importance of maternal constitutional factors and glucose intolerance of pregnancy in the development of newborn macrosomia.
TLDR
By multivariate analysis, maternal constitutional factors are more powerful predictors of newborn macrosomia than maternal mild glucose intolerance and treatment of mothers with GDM may be masking the effect of more pronounced carbohydrate intolerance.
Gestational diabetes mellitus. Unresolved issues and future research directions.
TLDR
The controversial aspects of gestational diabetes (GDM) are summarized and readers are introduced to possible relevant research questions that could be examined to provide clinicians with good-quality data on which to base decisions about this relatively common pregnancy-related issue.
Performance profile of an outcome measure: morbidity assessment index for newborns
TLDR
The MAIN score fulfills the need for a simple, universal, yet sensitive and robust tool to provide a numerical index of early neonatal outcomes of prenatal care and adverse prenatal exposures in babies delivered beyond 28 weeks gestation.
Relationship between plasma glucose levels in glucose-intolerant women and newborn macrosomia.
TLDR
The results demonstrated no significant impact of plasma glucose values from GCT, OGTT, AF, or APP on macrosomia in both "GCT-positive OGTT-negative" and GDM (treated) groups.
Association between maternal and child leptin levels 9 years after pregnancy complicated by gestational diabetes.
TLDR
There is an association between maternal and child leptin levels 9 years after a pregnancy complicated by gestational diabetes, and this research suggests that child leptin at 9 years serves as a marker for incipient insulin resistance.
Unresolved issues andfuture research directions
TLDR
Until suchtrials are completed, continuing with a standard approach to screening, diagnosis, and treatment, such as that suggested by the third international workshop on GDM, is recommended.
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