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Physiology of microglia.
TLDR
Current studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains, and microglial cells are considered the most susceptible sensors of brain pathology.
Neuroinflammation in Alzheimer's disease
Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons.
TLDR
The endoplasmic reticulum is the largest single intracellular organelle, which is present in all types of nerve cells, and regulated ER Ca(2+) release controls many neuronal functions, from plasmalemmal excitability to synaptic plasticity.
Physiology of Astroglia.
TLDR
Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Reactive astrocyte nomenclature, definitions, and future directions.
TLDR
It is advocated, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models.
Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease
TLDR
3xTg-AD mice have an impaired ability to generate new neurones in the DG of the hippocampus, the severity of which increases with age and might be directly associated with the known cognitive impairment observed from 6 months of age onwards.
Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons In Situ
TLDR
It is proposed that direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism.
NMDA Receptors Mediate Neuron-to-Glia Signaling in Mouse Cortical Astrocytes
TLDR
It is concluded that cortical astrocytes express functional NMDA receptors that are devoid of Mg2+ block, and these receptors are involved in neuronal–glial signal transmission.
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