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Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.
The proapoptotic influenza A virus PB1-F2 protein contributes to viral pathogenicity and is present in most human and avian influenza isolates. The structures of full-length PB1-F2 of the influenzaExpand
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Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-termExpand
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Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin.
PURPOSE Congenital stromal corneal dystrophy (CSCD) is an autosomal dominant condition with clouding of the cornea due to stromal opacities. It is caused by mutations in the decorin gene (DCN)Expand
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Multiple roles of annexin A2 in post-transcriptional regulation of gene expression.
Increasing evidence points to the participation of the multifunctional protein Annexin A2 (AnxA2) in mRNA localisation as well as the translation of certain mRNAs on cytoskeleton-bound polysomes, andExpand
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Protein phosphorylation and its role in the regulation of Annexin A2 function.
BACKGROUND Annexin A2 (AnxA2) is a multifunctional protein involved in endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal transduction, protein assembly, transcriptionExpand
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Arrivals and departures at the plasma membrane: direct and indirect transport routes
Studies carried out during the last 2 decades have dramatically increased our knowledge of the pathways and mechanisms of intracellular membrane traffic, most recently due to the developments inExpand
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Compartmentalization of polysomes into free, cytoskeletal-bound and membrane-bound populations.
Introduction A knowledge of transcriptional and post-transcriptional control mechanisms is essential for the full understanding of cell growth, cellular responses to hormonal stimulation and cellExpand
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Annexin A2 binds to the localization signal in the 3′ untranslated region of c‐myc mRNA
Messenger RNA trafficking, which provides a mechanism for local protein synthesis, is dependent on cis‐acting sequences in the 3′ untranslated regions (3′UTRs) of the mRNAs concerned acting togetherExpand
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Annexin II is associated with mRNAs which may constitute a distinct subpopulation.
Protein-mRNA interactions affect mRNA transport, anchorage, stability and translatability in the cytoplasm. During the purification of three subpopulations of polysomes, it was observed that a 36-kDaExpand
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Annexin A2 recognises a specific region in the 3'-UTR of its cognate messenger RNA.
Annexin A2 is a multifunctional Ca(2+)- and lipid-binding protein. We previously showed that a distinct pool of cellular Annexin A2 associates with mRNP complexes or polysomes associated with theExpand
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