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Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling.
- A. Val-Blasco, M. J. Piedras, +15 authors M. Fernández-Velasco
- Journal of the American College of Cardiology
- 31 January 2017
BACKGROUND Heart failure (HF) is a complex syndrome associated with a maladaptive innate immune system response that leads to deleterious cardiac remodeling. However, the underlying mechanisms of… Expand
Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes.
- J. A. Navarro-García, C. Delgado, +16 authors G. Ruiz-Hurtado
- Nephrology, dialysis, transplantation : official…
- 1 November 2019
Background Cardiac dysfunction and arrhythmia are common and onerous cardiovascular events in end-stage renal disease (ESRD) patients, especially those on dialysis. Fibroblast growth factor (FGF)-23… Expand
Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia.
- M. Tamayo, A. Fulgencio-Covián, +9 authors M. Fernández-Velasco
- Medicine, Chemistry
- Biochimica et biophysica acta. Molecular basis of…
Propionic acidemia (PA) is a rare metabolic disease associated with mutations in genes encoding the α and β subunits of the enzyme propionyl-CoA carboxylase. The accumulation of toxic metabolites… Expand
NOD1 activation in cardiac fibroblasts induces myocardial fibrosis in a murine model of type 2 diabetes.
- A. Val-Blasco, P. Prieto, +10 authors M. Fernández-Velasco
- The Biochemical journal
- 1 February 2017
Cardiac fibrosis and chronic inflammation are common complications in type 2 diabetes mellitus (T2D). Since nucleotide oligomerization-binding domain 1 (NOD1), an innate immune receptor, is involved… Expand
Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse
- Nieves Gómez-Hurtado, A. Dominguez-Rodriguez, +7 authors C. Delgado
- Medicine, Chemistry
- The Journal of physiology
- 1 July 2017
Leptin, is a 16 kDa pleiotropic peptide not only primarily secreted by adipocytes, but also produced by other tissues, including the heart. Controversy exists regarding the adverse and beneficial… Expand
Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.
BACKGROUND Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol may also induce… Expand
Calcitriol (1, 25-Dihydroxy Vitamin D3) increases L-Type Calcium Current via PKA Signalling and Modulates Calcium Cycling and Contractility in Isolated Mouse Ventricular Myocytes
BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol may also induce… Expand
Innate Immune Receptors, Key Actors in Cardiovascular Diseases
- Rafael I. Jaén, A. Val-Blasco, +6 authors M. Fernández-Velasco
- JACC. Basic to translational science
- 1 July 2020
BML‐111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis
- Rafael I. Jaén, M. Fernández-Velasco, +7 authors P. Prieto
- FASEB journal : official publication of the…
- 16 June 2020
Myocarditis is an inflammation of the myocardium that can progress to a more severe phenotype of dilated cardiomyopathy (DCM). Three main harmful factors determine this progression: inflammation,… Expand
Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure
- A. Val-Blasco, J. A. Navarro-García, +9 authors M. Fernández-Velasco
- Chemistry, Medicine
- Front. Physiol.
- 14 June 2018
Heart failure (HF) is a complex syndrome characterized by cardiac dysfunction, Ca2+ mishandling, and chronic activation of the innate immune system. Reduced cardiac output in HF leads to compensatory… Expand