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Effect of anabolic steroids on platelet proliferation
The aim of this investigation was to study the action of anabolic steroids on thymocyte proliferation in vitro, incorporation of 3H-thymidine into thymocytes, and the DNA content and weight of the thymus of experimental animals in experiments in vivo. Expand
[Antiproliferative and antioxidant activity of new dihydroquercetin derivatives].
There is a strong correlation (with a correlation coefficient of 0.93) between the antiproliferative effects of dihydroquercetin derivatives on murine skin fibroblasts and MCF-7 cells (human breast cancer). Expand
Synthesis and Antiproliferative Activity of New Acylcatechins
New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechinsExpand
6α-Methyl-16α,17α-Cyclohexane Progesterone and Progesterone Inhibit Growth of Doxorubicin-Sensitive MCF-7 and HeLa Tumor Cells
Temporal and concentration dependencies of the effects of gestagens (6α-methylpentarane and progesterone) and cytostatic doxorubicin on proliferation of MCF-7 and HeLa tumor cells was studied usingExpand
Isomeric derivatives of triazoles as new toxic decomposition products of 1,1-dimethylhydrazine.
The cytotoxicity of the isolated compounds has been preliminarily studied and found to be similar to UDMH or higher. Expand
Molecular-biological problems of drug design and mechanism of drug action
The cytotoxicities of capecitabine (Lab Tutour, Argentina) and xeloda (Roche) have been compared with respect to MCF-7 (human breast cancer cell line), HT-12 (colon cancer), and rat thymocytes by theExpand
[A new Russian gestagen with anticancer activity].
Results obtained in a complex study of ABMP demonstrate that the substance should be studied in clinical setting as a gestagen with anticancer and chemiosensitizing activity for further application to therapy of hyperplastic processes in the female genital system and tumors that are sensitive to female sex hormones. Expand
[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one].
The new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one is capable of suppressing the viability of human breast carcinoma and human cervical carcinoma, being comparable or even more effective than the reference drugs. Expand
Synthesis and Cytostatic Activity of some Pregna-D′-Pentaranes on HeLa Cell Culture
The effects of nine new pregnane steroids containing substituents in the 16α,17α- and/or 3-, 6-, and 19-positions of the steroid framework on the viability of HeLa cervical cancer cells were studied.Expand
Steroid hormones modulate lipid spectrum in lysosomal membranes of skin fibroblasts
It is shown that estradiol and hydrocortisone modulate lipid composition and affect lipidprotein interaction in fibroblast lysosome membranes, which can promote enzyme release from lysosomes. TheseExpand