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Iron loading site on the Fe–S cluster assembly scaffold protein is distinct from the active site
Iron–sulfur (Fe–S) cluster containing proteins are utilized in almost every biochemical pathway. The unique redox and coordination chemistry associated with the cofactor allows these proteins toExpand
Iron chaperones for mitochondrial Fe-S cluster biosynthesis and ferritin iron storage.
Protein controlled iron homeostasis is essential for maintaining appropriate levels and availability of metal within cells. Recently, two iron chaperones have been discovered that direct metal withinExpand
Proton-Induced Reactivity of NO– from a {CoNO}8 Complex
Research on the one-electron reduced analogue of NO, namely nitroxyl (HNO/NO–), has revealed distinguishing properties regarding its utility as a therapeutic. However, the fleeting nature of HNOExpand
Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster
Significance Cleavage and polyadenylation specificity factor 30 (CPSF30) is part of a complex of proteins, collectively called CPSF, that direct pre-mRNA processing. CSPF30 is classified as aExpand
Discovery of enzymes for toluene synthesis from anoxic microbial communities
Microbial toluene biosynthesis was reported in anoxic lake sediments more than three decades ago, but the enzyme catalyzing this biochemically challenging reaction has never been identified. Here weExpand
Shikimate kinase (EC from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development.
The enzymes of the shikimate pathway represent potential molecular targets for the development of non-toxic antimicrobial agents and anti-parasite drugs. One of the most promising of these enzymes isExpand
Synthesis of Co(II)-NO(-) Complexes and Their Reactivity as a Source of Nitroxyl.
Metal-nitroxyl (M-HNO/M-NO(-)) coordination units are found in denitrification enzymes of the global nitrogen cycle, and free HNO exhibits pharmacological properties related to cardiovascularExpand
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity
BackgroundGeranylgeranyl reductase (GGR) is a flavin-containing redox enzyme that hydrogenates a variety of unactivated polyprenyl substrates, which are further processed mostly for lipidExpand
Insight into the Mechanism of Phenylacetate Decarboxylase (PhdB), a Toluene‐Producing Glycyl Radical Enzyme
We recently reported the discovery of phenylacetate decarboxylase (PhdB), representing one of only ten glycyl‐radical‐enzyme reaction types known, and a promising biotechnological tool for first‐timeExpand
Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1".
Mitochondrial Fe-S cluster biosynthesis is accomplished within yeast utilizing the biophysical attributes of the "Isu1" scaffold assembly protein. As a member of a highly homologous protein family,Expand