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Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) disease. It is nowExpand
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Severe Tuberculosis in Humans Correlates Best with Neutrophil Abundance and Lymphocyte Deficiency and Does Not Correlate with Antigen-Specific CD4 T-Cell Response
It is generally thought that Mycobacterium tuberculosis (Mtb)-specific CD4+ Th1 cells producing IFN-γ are essential for protection against tuberculosis (TB). In some studies, protection has recentlyExpand
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The first representative vertebrate fauna from the late Miocene of Southern European Russia
508 The land vertebrate fauna from the Miocene of southern European Russia is poorly investigated. This is caused by a wide spread in this region of marine deposits of the Paratethys and restrictedExpand
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A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents.
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCGExpand
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Th1, Th17, and Th1Th17 Lymphocytes during Tuberculosis: Th1 Lymphocytes Predominate and Appear as Low-Differentiated CXCR3+CCR6+ Cells in the Blood and Highly Differentiated CXCR3+/−CCR6− Cells in
Th1 lymphocytes are considered the main mediators of protection against tuberculosis (TB); however, their phenotypic characteristics and relationship with Th17 and Th1Th17 populations during TB areExpand
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Antigen-Specific IFN-γ Responses Correlate with the Activity of M. tuberculosis Infection but Are Not Associated with the Severity of Tuberculosis Disease
IFN-γ is a key cytokine in antituberculosis (TB) defense. However, how the levels of its secretion affect M. tuberculosis (Mtb) infection is not clear. We have analyzed associations between IFN-γExpand
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[Prolonged regional intra-arterial therapy in multimodal treatment of patients with severe skeletal trauma].
A total of 108 victims with open fractures of long tubular bones of different localization are examined. Regional intraarterial therapy was added to their treatment protocols. Stable functionalExpand
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[Expression of early hematopoietic markers in cord blood and mobilized blood].
G-CSF mobilized peripheral blood and cord blood are major sources of hematopoietic progenitor cells. These cells are characterized by the expression of "early" antigens. We have evaluated theExpand
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Expression of early hematopoietic markers in cord and mobilized blood
G-CSF mobilized peripheral blood and cord blood are major sources of hematopoietic progenitor cells. These cells are characterized by expression of “early” antigens. We have evaluated theExpand
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Morphology of the Coracoid of Late Cretaceous Enantiornithines (Aves: Enantiornithes) from Dzharakuduk (Uzbekistan)
Based on serial material from the Turonian of Dzharakuduk (central Kyzyl Kum, Uzbekistan), the morphology of coracoid of enantiornithines is described in detail. Variants of each morphologicalExpand
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