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Synthesis of tritium‐labelled biologically active analogues of progesterone by selective hydrogenation of 16α,17α‐cyclohex‐3′‐en‐pregna‐1,4‐dien‐3,20‐dione
The procedure of selective hydrogenation with gaseous tritium of 16α,17α-cyclohex-3'-en-pregna-1,4-dien-3,20-dione (StO) has been elaborated, and isotopically labelledExpand
Cardiotonic Steroids Differentially Affect Intracellular Na+ and [Na+]i/[K+]i-independent Signaling in C7-MDCK Cells*
Recently, we reported that ouabain kills renal epithelial and vascular endothelial cells independently of elevation of the [Na+]i/[K+]i ratio. These observations raised the possibility of findingExpand
Synthesis of [3H]-cycloalkanoprogesterones (pregna-d'-pentaranes) and study of their interaction with a progesterone receptor
In order to search target organs and to study the mechanism of the action of steroids with separated biological functions, tritium-labeled pregna-d'-pentaranes were synthesized by an originalExpand
Synthesis of 19-substituted steroids of the 16α,17α-cyclohexanopregnane series and study of their interactions with rat uterine cytosol and blood serum proteins
New 16α,17α-cyclohexanopregnanes (pregna-D′6-pentaranes) containing alkyl or heteroatomic substituents in position 19, namely, 19-methylidene-, 19-methyl-, 19-methoxyimino-, andExpand
Structural Features of Pregna-D′-pentaranes Determining Their Interaction with Three Rat Proteins
Competition of a number of progesterone 16α,17α-cycloalkane derivatives with 3H-labeled ligands for the binding sites of rat uterine progesterone receptor, uterine pentaranophilin, and blood serumExpand
The Synthesis of Tritium-Labeled 16α,17α-Cyclohex-3′-eno-progesterone as Probe for the Study of Steroid–Receptor Binding
Abstract Tritium-labeled 16α,17α-cyclohex-3′-en-pregn-4-en-3,20-dione (16α, 17α-cyclohex-3′-eno-progesterone) with specific activity of 44 Ci/mmol, required in studying of binding with progesteroneExpand
Species and Tissue Distribution of Proteins Binding 16α,17α-Cycloalkanoprogesterone Derivatives
The binding of [3H]progesterone and [3H]16α,17α-cycloalkanoprogesterones to proteins from rat, rabbit, and human uteri and other organs was studied. We found that 16α,17α-cycloalkanoprogesteroneExpand
Morphological Changes in Rat Uterus Tissues under the Action of Progestins and Antiprogestins of the Pregna-D"-pentaran Series
Changes in the uterus morphology of mature female rats were studied on the model of pseudopregnancyafter treatment with the progestin 16α,17α-cyclohexanoprogesterone (PR) and the antirpogestinsExpand