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Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin
- T. Kitamura, T. Tange, +7 authors F. Takaku
- Biology, Medicine
- Journal of cellular physiology
- 1 August 1989
We have established a novel cell line, designated as TF‐1, from a patient with erythroleukemia, which showed complete growth dependency on granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) or… Expand
Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue.
A human lung cancer (OTUK-tumor) was transplanted serially to nude mice, which invariably developed a marked neutrophilia. In order to analyze this phenomenon, in vitro agar culture studies were… Expand
Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan.
We report the results of a randomized study to elucidate whether addition of granulocyte colony-stimulating factor (G-CSF) to immunosuppressive therapy is valuable for the treatment of severe… Expand
Identification and analysis of human erythropoietin receptors on a factor-dependent cell line, TF-1.
We have recently established a novel cell line, TF-1, from bone marrow cells of a patient with erythroleukemia, that showed an absolute growth dependency on each of three hematopoietic growth… Expand
A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders
A sensitive sandwich enzyme‐linked immunosorbent assay (ELISA) has been established to estimate serum thrombopoietin (TPO) concentrations in healthy volunteers and patients with haemopoietic… Expand
A Multicenter, Open-Label Clinical Study of Micafungin (FK463) in the Treatment of Deep-seated Mycosis in Japan
- S. Kohno, T. Masaoka, +5 authors H. Ikemoto
- Biology, Medicine
- Scandinavian journal of infectious diseases
- 1 May 2004
The efficacy and safety of micafungin (FK463), which is a new lipopeptide antifungal agent of the echinocandin class and is active against both Aspergillus and Candida species, were investigated in… Expand
Epithelioid Hemangioma Versus Kimura's Disease: A Comparative Clinicopathologic Study A Comparative Clinicopathologic Study
A clinicopathologic and immunohistochemical study of eight cases of epithelioid hemangioma and 11 cases of Kimura's disease was performed. Patients with epithelioid hemangioma (EH) ranged in age from… Expand
Long‐term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA…
Immunosuppressive therapy has been employed as the initial treatment for acquired chronic pure red cell aplasia (PRCA), such as idiopathic, thymoma‐associated, or large granular lymphocyte (LGL)… Expand
Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group.
BACKGROUND AND OBJECTIVES Cyclosporine A (CsA) has become one of the leading agents for the treatment of pure red cell aplasia (PRCA). However, further studies are necessary to determine the… Expand
Recombinant human granulocyte colony-stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor-mediated agonists and stimulation of C3bi receptor…
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide release and membrane depolarization in parallel in human granulocytes stimulated by the receptor-mediated… Expand