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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration and maintenance but also promotes development of hepatocellular carcinoma (HCC). Despite extensive… Expand
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH), disorders that increase… Expand
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Nuclear factor κB (NF-κB), a key activator of inflammation, primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents excessive… Expand
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate… Expand
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
Background Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte… Expand
Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes
- Akiko Nagaishi, M. Takagi, +6 authors K. Tanaka
- Journal of Neurology, Neurosurgery & Psychiatry
- 10 June 2011
Objective To analyse clinicoepidemiological features of neuromyelitis optica in a large cohort and to compare the differences between onset age, gender and clinical phenotypes. Methods… Expand
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.
Obesity can result in insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) and increases liver cancer risk. Obesity-induced insulin resistance depends, in part, on chronic… Expand
Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
- Hayato Nakagawa, Y. Hikiba, +17 authors S. Maeda
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 6 January 2014
Significance The precise roles of E-cadherin in the liver and liver carcinogenesis are still unknown. Here we show that mice lacking E-cadherin in the liver develop spontaneous periportal… Expand
Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease
Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the… Expand
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan.
- T. Okanoue, A. Umemura, K. Yasui, Y. Itoh
- Journal of gastroenterology and hepatology
- 4 January 2011
During the past 20 to 30 years, the frequency of patients presenting with nonalcoholic fatty liver diseases (NAFLD) has increased gradually in Japan in proportion to the increase in the population… Expand