Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
- Brendan J Floyd, Emily M. Wilkerson, +21 authors D. J. Pagliarini
- Biology, Medicine
- Molecular cell
- 18 August 2016
Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we assessed… Expand
The One Hour Yeast Proteome*
- Alexander S. Hebert, A. Richards, +4 authors J. Coon
- Chemistry, Medicine
- Molecular & Cellular Proteomics
- 19 October 2013
We describe the comprehensive analysis of the yeast proteome in just over one hour of optimized analysis. We achieve this expedited proteome characterization with improved sample preparation,… Expand
Formic-acid-induced depolymerization of oxidized lignin to aromatics
- Alireza Rahimi, A. Ulbrich, J. Coon, S. Stahl
- Chemistry, Medicine
- Nature
- 13 November 2014
Lignin is a heterogeneous aromatic biopolymer that accounts for nearly 30% of the organic carbon on Earth and is one of the few renewable sources of aromatic chemicals. As the most recalcitrant of… Expand
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis
- Danielle C. Lohman, F. Forouhar, +19 authors D. J. Pagliarini
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 22 October 2014
Significance Coenzyme Q (CoQ) is a requisite component of the mitochondrial oxidative phosphorylation machinery that produces more than 90% of cellular ATP. Despite the discovery of CoQ more than 50… Expand
Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.
- Jonathan A. Stefely, Andrew G. Reidenbach, +14 authors D. J. Pagliarini
- Biology, Medicine
- Molecular cell
- 19 November 2014
The ancient UbiB protein kinase-like family is involved in isoprenoid lipid biosynthesis and is implicated in human diseases, but demonstration of UbiB kinase activity has remained elusive for… Expand
Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling
- Jonathan A. Stefely, Nicholas W. Kwiecien, +17 authors J. Coon
- Biology, Medicine
- Nature Biotechnology
- 31 August 2016
Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin… Expand
Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes
- Pooja Jha, Molly T. McDevitt, +11 authors J. Auwerx
- Biology, Medicine
- Cell systems
- 13 June 2018
SUMMARY The genetic regulation and physiological impact of most lipid species are unexplored. Here, we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference… Expand
Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification
- D. H. Keating, Y. Zhang, +18 authors R. Landick
- Biology, Medicine
- Front. Microbiol.
- 13 August 2014
Efficient microbial conversion of lignocellulosic hydrolysates to biofuels is a key barrier to the economically viable deployment of lignocellulosic biofuels. A chief contributor to this barrier is… Expand
Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
- Pooja Jha, Molly T. McDevitt, +10 authors D. J. Pagliarini
- Biology, Medicine
- Cell systems
- 27 June 2018
The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice… Expand
Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production.
- Mike T. Veling, Andrew G. Reidenbach, +9 authors D. J. Pagliarini
- Biology, Medicine
- Molecular cell
- 7 December 2017
Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse… Expand