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High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity. The enzymeExpand
Piper sarmentosum inhibits ICAM-1 and Nox4 gene expression in oxidative stress-induced human umbilical vein endothelial cells
BackgroundAqueous extract of Piper sarmentosum (AEPS) is known to possess antioxidant and anti-atherosclerotic activities but the mechanism responsible for it remains unclear. In early part ofExpand
Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity
Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Prolonged excessive alcohol intake contributes to increased production ofExpand
Piper Sarmentosum Increases Nitric Oxide Production in Oxidative Stress: A Study on Human Umbilical Vein Endothelial Cells
OBJECTIVE: Nitric oxide produced by endothelial nitric oxide synthase (eNOS) possesses multiple anti-atherosclerotic properties. Hence, enhanced expression of eNOS and increased Nitric oxide levelsExpand
Flavonoids of Piper sarmentosum and its cytoprotective effects against oxidative stress
Abnormalities in endothelial cell structure and function may lead to diseases such as thrombosis and atherosclerosis. Oxidative stress plays an important role in the pathogenesis of variousExpand
Effect of early clinical skills teaching on 3rd year medical students' learning: The student perspective
Abstract Objectives The main purpose of the early introduction of Clinical Skills Learning (CSL) to pre-clinical years is to allow medical students to gain experience in clinical examination skills,Expand
The assessment of finger photoplethysmography fitness index (PPGF) among young men with cardiovascular disease risk factors: a cross sectional study
Two new vascular health markers which are derived from finger photoplethysmography (PPG) waveform have been introduced based on Malaysian population, namely PPG fitness index (PPGF) and vascular riskExpand
Assessment of learning environment among the first year Malaysian medical students
Abstract Objectives The quality of the learning environment has been identified to be crucial for effective learning. Medical students' perceptions of learning environments provide a usefulExpand
Evaluation of Finger Photoplethysmography Fitness Index on Young Women with Cardiovascular Disease Risk Factors
The use of photoplethysmography (PPG) as one of cardiovascular disease (CVD) marker has got more attention due to its simplicity, noninvasive and portable characteristics. Two new markers had beenExpand
Piper sarmentosum as an Antioxidant: A Systematic Review
Piper sarmentosum (PS) is an herb with various medicinal properties. The antioxidant activity of PS contributes to many of its pharmacological effects such as anti-hypertension, anti-cancer andExpand