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- Publications
- Influence
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
- S. Mazmanian, C. H. Liu, A. Tzianabos, D. Kasper
- Biology, Medicine
- Cell
- 15 July 2005
The mammalian gastrointestinal tract harbors a complex ecosystem consisting of countless bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership has potential for… Expand
Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function.
- A. Tzianabos
- Biology, Medicine
- Clinical microbiology reviews
- 1 October 2000
Polysaccharide immunomodulators were first discovered over 40 years ago. Although very few have been rigorously studied, recent reports have revealed the mechanism of action and structure-function… Expand
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
- Q. Wang, R. McLoughlin, +5 authors D. Kasper
- Biology, Medicine
- The Journal of experimental medicine
- 25 December 2006
Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis, activates CD4+ T cells, resulting in a Th1… Expand
Cytokines, allergy, and asthma
- Ly P Ngoc, D. Gold, A. Tzianabos, S. Weiss, J. Celedón
- Medicine
- Current opinion in allergy and clinical…
- 1 April 2005
Purpose of reviewThis review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early… Expand
Polysaccharide Processing and Presentation by the MHCII Pathway
- B. Cobb, Q. Wang, A. Tzianabos, D. Kasper
- Biology, Medicine
- Cell
- 28 May 2004
The adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility complex antigen presentation to CD8(+)… Expand
Structural features of polysaccharides that induce intra-abdominal abscesses.
- A. Tzianabos, A. Onderdonk, B. Rosner, R. Cisneros, D. Kasper
- Biology, Medicine
- Science
- 15 October 1993
The capsular polysaccharide complex from Bacteroides fragilis promotes the formation of intra-abdominal abscesses--a pathologic host response to infecting microorganisms. This complex consists of two… Expand
Extensive surface diversity of a commensal microorganism by multiple DNA inversions
- C. Krinos, M. Coyne, K. Weinacht, A. Tzianabos, D. Kasper, L. Comstock
- Biology, Medicine
- Nature
- 29 November 2001
The dynamic interactions between a host and its intestinal microflora that lead to commensalism are unclear. Bacteria that colonize the intestinal tract do so despite the development of a specific… Expand
Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide
- R. Malley, A. Srivastava, +4 authors P. Anderson
- Biology, Medicine
- Infection and Immunity
- 1 April 2006
ABSTRACT Serotype-specific immunity to Streptococcus pneumoniae is conferred by antibodies to the capsular polysaccharides, which define the 90 known serotypes. Whether antibody to the species-common… Expand
A Defined O-Antigen Polysaccharide Mutant of Francisella tularensis Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity
- S. Sebastian, S. Dillon, +8 authors D. Kasper
- Biology, Medicine
- Infection and Immunity
- 12 February 2007
ABSTRACT Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol,… Expand
CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism 1
- D. R. Chung, D. Kasper, +4 authors A. Tzianabos
- Biology, Medicine
- The Journal of Immunology
- 15 February 2003
Abscess formation associated with intra-abdominal sepsis causes severe morbidity and can be fatal. Previous studies have implicated T cells in the pathogenesis of abscess formation, and we have… Expand