A. Tzianabos

Publications85
h-index39
Citations7,012
Highly Influential Citations227
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An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
The mammalian gastrointestinal tract harbors a complex ecosystem consisting of countless bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership has potential for… Expand
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Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function.
  • A. Tzianabos
  • Biology, Medicine
  • Clinical microbiology reviews
  • 1 October 2000
Polysaccharide immunomodulators were first discovered over 40 years ago. Although very few have been rigorously studied, recent reports have revealed the mechanism of action and structure-function… Expand
  • 572
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  • PDF
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis, activates CD4+ T cells, resulting in a Th1… Expand
  • 211
  • 12
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Cytokines, allergy, and asthma
Purpose of reviewThis review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early… Expand
  • 307
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Polysaccharide Processing and Presentation by the MHCII Pathway
The adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility complex antigen presentation to CD8(+)… Expand
  • 281
  • 9
Structural features of polysaccharides that induce intra-abdominal abscesses.
The capsular polysaccharide complex from Bacteroides fragilis promotes the formation of intra-abdominal abscesses--a pathologic host response to infecting microorganisms. This complex consists of two… Expand
  • 247
  • 8
Extensive surface diversity of a commensal microorganism by multiple DNA inversions
The dynamic interactions between a host and its intestinal microflora that lead to commensalism are unclear. Bacteria that colonize the intestinal tract do so despite the development of a specific… Expand
  • 260
  • 8
Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide
ABSTRACT Serotype-specific immunity to Streptococcus pneumoniae is conferred by antibodies to the capsular polysaccharides, which define the 90 known serotypes. Whether antibody to the species-common… Expand
  • 171
  • 8
A Defined O-Antigen Polysaccharide Mutant of Francisella tularensis Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity
ABSTRACT Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol,… Expand
  • 67
  • 6
CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism 1
Abscess formation associated with intra-abdominal sepsis causes severe morbidity and can be fatal. Previous studies have implicated T cells in the pathogenesis of abscess formation, and we have… Expand
  • 223
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