• Publications
  • Influence
A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.
BACKGROUND Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative benefits of prophylactic antiemeticExpand
  • 1,235
  • 65
  • PDF
Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery: Toward an Empirical Definition of Hypotension
Background:Intraoperative hypotension may contribute to postoperative acute kidney injury (AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors evaluated theExpand
  • 485
  • 17
  • PDF
Adding Dexmedetomidine to Lidocaine for Intravenous Regional Anesthesia
Dexmedetomidine is approximately 8 times more selective toward the &agr;-2-adrenoceptors than clonidine. It decreases anesthetic requirements by up to 90% and induces analgesia in patients. WeExpand
  • 231
  • 14
Intravenous acetaminophen reduces postoperative nausea and vomiting: A systematic review and meta-analysis
Summary Prophylactically administered intravenous acetaminophen for postsurgical pain reduces postoperative nausea and vomiting. This effect is unrelated to the opioid‐sparing effect, but correlatesExpand
  • 147
  • 9
  • PDF
Analgesic Effects of Gabapentin after Spinal Surgery
BackgroundA combination of opioid and nonopioid analgesic drugs may improve the quality of postoperative analgesia as well as reduce opioid requirements and their associated side effects. StudiesExpand
  • 247
  • 8
  • PDF
Relationship Between Intraoperative Mean Arterial Pressure and Clinical Outcomes After Noncardiac Surgery: Toward an Empirical Definition of Hypotension
Fourteen patients were ventilated with pressure support ventilation or Intellivent, in a random order, for two 24-h periods during weaning from mechanical ventilation. Intellivent improved theExpand
  • 223
  • 8
Who Is at Risk for Postdischarge Nausea and Vomiting after Ambulatory Surgery?
Background: About one in four patients suffers from postoperative nausea and vomiting. Fortunately, risk scores have been developed to better manage this outcome in hospitalized patients, but thereExpand
  • 141
  • 7
  • PDF
Effect of oral gabapentin on postoperative epidural analgesia.
BACKGROUND Gabapentin has been used successfully as a non-opioid analgesic adjuvant for postoperative pain management. We hypothesized that gabapentin might be a useful adjuvant for postoperativeExpand
  • 112
  • 7
  • PDF
Gabapentin: An Alternative to the Cyclooxygenase-2 Inhibitors for Perioperative Pain Management
The cyclooxygenase-2 inhibitor, rofecoxib, was a popular analgesic adjuvant for improving perioperative pain management. We designed this placebo-controlled study to test the hypothesis thatExpand
  • 124
  • 6