• Publications
  • Influence
Transformation of tooth type induced by inhibition of BMP signaling.
Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic geneExpand
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The cutting-edge of mammalian development; how the embryo makes teeth
A wealth of information has recently become available on the molecular signals that are required to form and pattern the dentition in the mouse, shedding light on how important decisions about toothExpand
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eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus.
Classical embryological experiments suggest that a posterior signal is required for patterning the developing anteroposterior axis. In this paper, we investigate a potential role for FGF signallingExpand
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Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development.
LIM-homeobox containing (Lhx) genes encode trascriptional regulators which play critical roles in a variety of developmental processes. We have identified two genes belonging to a novel subfamily ofExpand
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Salivary gland development.
  • A. Tucker
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 April 2007
Salivary glands provide an excellent model for the study of epithelial-mesenchymal interactions and branching morphogenesis. This review will discuss the anatomy of different types of glands, in aExpand
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Gene defect in ectodermal dysplasia implicates a death domain adapter in development
Members of the tumour-necrosis factor receptor (TNFR) family that contain an intracellular death domain initiate signalling by recruiting cytoplasmic death domain adapter proteins. Edar is a deathExpand
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Homeotic transformation of branchial arch identity after Hoxa2 overexpression.
Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch cartilages, such as Meckel's and the quadrate, into second arch elements, such as the tongueExpand
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Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.
The molecular events of odontogenic induction are beginning to be elucidated, but until now nothing was known about the molecular basis of the patterning of the dentition. A role for Dlx-1 and Dlx-2Expand
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Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition.
Development of the mammalian tooth has been intensively studied as a model system for epithelial/mesenchymal interactions during organogenesis, and progress has been made in identifying key moleculesExpand
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Fgf-8 determines rostral-caudal polarity in the first branchial arch.
In mammals, rostral ectomesenchyme cells of the mandibular arch give rise to odontogenic cells, while more caudal cells form the distal skeletal elements of the lower jaw. Signals from the epitheliumExpand
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