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A population-based validation study of the DCIS Score predicting recurrence risk in individuals treated by breast-conserving surgery alone
Validated biomarkers are needed to improve risk assessment and treatment decision-making for women with ductal carcinoma in situ (DCIS) of the breast. The Oncotype DX® DCIS Score (DS) was shown toExpand
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Role of the metastasis-promoting protein osteopontin in the tumour microenvironment
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multiple post‐translational modifications, including phosphorylation, glycosylation, proteolyticExpand
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Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.
Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to the propensity of primary breast tumors to metastasize to regional and distant sites. Metastatic spread afterExpand
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Osteopontin expression in a group of lymph node negative breast cancer patients
The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors ofExpand
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Pre- and post-translational regulation of osteopontin in cancer
Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors including integrins and CD44. It is expressed in many tissues and secreted into body fluids includingExpand
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Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model.
Metastatic spread, not primary tumor burden, is the leading cause of breast cancer deaths. For patient prognosis to improve, new systemic adjuvant therapies that are capable of effectively inhibitingExpand
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Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.
Expression of hepatocyte growth factor (HGF) and HGF receptor (HGFR, product of the met proto-oncogene) mRNA were examined by nonisotopic in situ hybridization in a spectrum of benign and malignantExpand
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Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival.
Osteopontin (OPN) is a secreted, integrin-binding phosphoprotein that has been implicated in both normal and pathological processes; qualitative increases in OPN blood levels have been reported in aExpand
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A New Model for Lymphatic Metastasis: Development of a Variant of the MDA-MB-468 Human Breast Cancer Cell Line that Aggressively Metastasizes to Lymph Nodes
Breast cancer often spreads from the primary tumor to regional lymph nodes. Lymph node status provides clinically important information for making treatment decisions. Spread via lymphatics is alsoExpand
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Ras-responsive genes and tumor metastasis.
Transfected ras oncogenes have been shown to induce metastatic properties in some cells. Clarification of the mechanisms by which ras is able to increase the metastatic ability in model systems willExpand
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