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Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*
TLDR
OCTN2 is a physiologically important, high affinity sodium-carnitine cotransporter in humans, and the functional characteristics of OCTN2 coincide with those reported for plasma membrane carnitine transport. Expand
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
TLDR
Three novel transporters structurally belonging to the organic anion transporting polypeptide (OATP) family in humans are identified and OATP-C proved to be identical with the recently reported LST1/OatP-2. Expand
Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human
TLDR
The pH-sensitive activity of human organic anion transporting polypeptide OATP-B, which is expressed at the apical membrane of human small intestinal epithelial cells, was functionally characterized and clarification of factors, such as pH, that affect the OATp-B activity is essential for an understanding of the physiological and pharmacological relevance of the transporter in the small intestine. Expand
Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane
TLDR
OATP-B plays a role in the absorption of anionic compounds across the apical membrane of human intestinal epithelial cells, although it cannot be decisively concluded that pH-dependent absorption of pravastatin is determined by OATPB alone. Expand
Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice*
TLDR
OCTN3 is unique in its limited tissue distribution and Na+-independent carnitine transport, whereas OCTN1 efficiently transported TEA with minimal expression of carn itine transport activity and may have a different role from other members of the OCTN family. Expand
ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE
TLDR
This study is the first to yield evidence that OATP1B1 is involved in the hepatic disposition of SN-38 and that genetic polymorphisms of O ATP1 B1 may contribute to the known interpatient variability in disposition of irinotecan. Expand
Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1
TLDR
Although its subcellular localization and detailed functional characteristics are not clear at present, OCTN1 appears to be a novel proton antiporter that functions for active secretion of cationic compounds across the renal epithelial brush‐border membrane and may play a role in the renal excretion of xenobiotics and their metabolites. Expand
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
TLDR
These mutations provide the first evidence that loss of OCTN2 function causes primary systemic carnitine deficiency, an autosomal recessive disorder characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and hyperammonaemia. Expand
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
TLDR
The SNP of S486F may affect the physiological function and/or pharmacological effects of OATP-B substrates in vivo, and the kinetics of uptake of [(3)H]estrone-3-sulfate was determined. Expand
Functional Characterization of Human Organic Anion Transporting Polypeptide B (OATP-B) in Comparison with Liver-Specific OATP-C
TLDR
The functional characteristics of human organic anion transporter B (OATP-B) in comparison with those of the known, liver-specific O ATP-C were assessed to assess the specific recognition of sulfate conjugates that seems to be unique to OATp-B. Expand
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